SAB4503789
Anti-phospho-Tyrosine Hydroxylase (pSer40) antibody produced in rabbit
affinity isolated antibody
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
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biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 58 kDa
species reactivity
human, mouse, rat
concentration
~1 mg/mL
technique(s)
ELISA: 1:40000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
phosphorylation (pSer40)
Gene Information
human ... TH(7054)
General description
Tyrosine Hydroxylase (TH) is encoded by the gene mapped to human chromosome 11p15.5, close to the insulin (INS) and Harvey-ras-1 (HRAS) genes. The N-terminal end of the protein plays a vital role in maintaining intracellular stability of the enzyme. tyrosine hydroxylase is expressed in various tissues such as brain, adrenal medulla and sympathetically innervated tissues. The enzyme is characterized with a regulatory domain (R), a catalytic domain (C) at N-terminal end, and a coiled-coil domain at the C-terminal end.
Immunogen
The antiserum was produced against synthesized peptide derived from human Tyrosine Hydroxylase around the phosphorylation site of Ser40.
Immunogen Range: 41-90
Immunogen Range: 41-90
Biochem/physiol Actions
Tyrosine Hydroxylase (TH) specifically catalyzes the hydroxylation of the amino acid L-tyrosine to 3, 4-dihydroxy-L-phenylalanine (L-DOPA). TH is a rate-limiting enzyme involved in the synthesis of catecholamine, involved in several brain functions, such as attention, memory, cognition, and emotion. Phosphorylation of the N-terminal portion of tyrosine hydroxylase controls the degradation of this enzyme by the ubiquitin-proteasome pathway. Alteration in the expression of the gene results in the pathogenesis of Parkinson′s disease (PD). Point mutation in the gene coding for TH leads to Segawa′s syndrome.
Features and Benefits
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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K L O'Malley et al.
Nucleic acids research, 16(10), 4437-4446 (1988-05-25)
The gene for the catecholamine biosynthetic enzyme, tyrosine hydroxylase (TH), has been previously mapped to human chromosome 11 p15.5 in the vicinity of the loci for insulin (INS) and for the oncogene Harvey Ras 1 (HRAS). Here we show that
B Lüdecke et al.
Human genetics, 95(1), 123-125 (1995-01-01)
We have examined the molecular basis of Segawa's syndrome in six families with seven affected children. In one family two siblings with this disease carried a point mutation in exon 11 of the tyrosine hydroxylase gene, resulting in an amino
S Colette Daubner et al.
Archives of biochemistry and biophysics, 508(1), 1-12 (2010-12-24)
Tyrosine hydroxylase is the rate-limiting enzyme of catecholamine biosynthesis; it uses tetrahydrobiopterin and molecular oxygen to convert tyrosine to DOPA. Its amino terminal 150 amino acids comprise a domain whose structure is involved in regulating the enzyme's activity. Modes of
Christopher Tolleson et al.
CNS & neurological disorders drug targets, 11(4), 381-386 (2012-04-10)
Tyrosine hydroxylase (TH) is the rate limiting step in the biosynthesis of dopamine and other catecholamines. Differences have been noted in concentration and availability of this enzyme and its cofactors in disease states such as Parkinson's disease (PD) which are
Anees A Banday et al.
American journal of physiology. Renal physiology, 317(4), F949-F956 (2019-08-15)
The role of dopamine D1-like receptors (DR) in the regulation of renal Na+ transporters, natriuresis, and blood pressure is well established. However, the involvement of the angiotensin 1-7 (ANG 1-7)-Mas receptor in the regulation of Na+ balance and blood pressure
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