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Key Documents

S9549

Sigma-Aldrich

Superoxide dismutase–polyethylene glycol from bovine erythrocytes

lyophilized powder, ≥1,350 units/mg protein

Synonym(s):

PEG-SOD

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About This Item

MDL number:
UNSPSC Code:
12352204
NACRES:
NA.54

form

lyophilized powder

Quality Level

specific activity

≥1,350 units/mg protein

mol wt

5000 Da

composition

Protein, ≥20% biuret

extent of labeling

≥10 mol PEG per mol protein

storage temp.

−20°C

General description

Superoxide dismutase from bovine erythrocytes is a copper and zinc superoxide dismutase. Copper and zinc ions are coordinated by active site histidine residues. It has β-barrel structure.

Application

Superoxide dismutase-polyethylene glycol from bovine erythrocytes has been used:
  • in the incubation of lung slices for measurement of dihydroethidium (DHE) fluorescence in cultured bovine pulmonary artery endothelial cells
  • as supplement in T cell culture to investigate its effect on cytokine production
  • in the preincubation of the carotid artery sections prior to DHE treatment

Biochem/physiol Actions

Superoxide dismutase-polyethylene glycol (SOD-PEG) is effective than SOD in scavenging free radicals in injuries. It reduces oxidative damage in ovarian follicles cell culture and during ovarian tissue transplantation. SOD-PEG is also effective in scavenging superoxide in mitochondrial abnormalities.

Packaging

Package size based on protein content

Other Notes

Superoxide dismutase from bovine erythrocytes coupled to methoxy-polyethylene glycol, M.W. 5,000, through secondary amine linkage.

Physical form

Lyophilized powder containing PEG plus 5% citrate buffer salts

Preparation Note

Enzyme derived

Pictograms

Health hazard

Signal Word

Danger

Hazard Statements

Precautionary Statements

Hazard Classifications

Resp. Sens. 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Polyethylene glycol-superoxide dismutase prevents endotoxin-induced cardiac dysfunction
Supinski GS and Callahan LA
American Journal of Respiratory and Critical Care Medicine, 173(11), 1240-1247 (2006)
Pluronic modified leptin with increased systemic circulation, brain uptake and efficacy for treatment of obesity.
Yi X, Yuan D, Farr SA, et al.
Journal of Controlled Release : Official Journal of the Controlled Release Society, 191, 34-46 (2014)
Deficiency of superoxide dismutase promotes cerebral vascular hypertrophy and vascular dysfunction in hyperhomocysteinemia
Dayal S, et al.
PLoS ONE, 12(4), e0175732-e0175732 (2017)
Simone R Potje et al.
Free radical biology & medicine, 112, 587-596 (2017-09-14)
[Ru(terpy)(bdq)NO]
Roles of zinc and copper in modulating the oxidative refolding of bovine copper, zinc superoxide dismutase
Li HT, et al.
Acta biochimica et biophysica Sinica, 42(3), 183-194 (2010)

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