S7389

SB-269970 hydrochloride

powder, ≥98% (HPLC)

• Synonym(s): (R)-3-[2-[2-(4-Methylpiperidin-1-yl)ethyl]pyrrolidine-1-sulfonyl]phenol hydrochloride, SB 269970A
• Empirical Formula (Hill Notation): C₁₈H₂₈N₂O₃S · HCl
• CAS Number: 261901-57-9
• Molecular Weight: 388.95
• MDL number: MFCD03788020
• UNSPSC Code: 12352200
• PubChem Substance ID: 24278708
• NACRES: NA.77

Properties

• Assay: ≥98% (HPLC)
• form: powder
• optical activity: [α]/D 75 to 90°, c = 1.0 in DMSO
• storage condition: desiccated
• solubility: H₂O: 10 mg/mL, clear (warmed to 60 °C)
• storage temp.: 2-8°C
• SMILES string: Cl.CC1CCN(CC1)CC[C@H]2CCCN2S(=O)(=O)c3cccc(O)c3
• InChI: 1S/C18H28N2O3S.ClH/c1-15-7-11-19(12-8-15)13-9-16-4-3-10-20(16)24(22,23)18-6-2-5-17(21)14-18;/h2,5-6,14-16,21H,3-4,7-13H2,1H3;1H/t16-;/m1./s1
• InChI key: XQCJOYZLWFNDIO-PKLMIRHRSA-N
• Gene Information: human ... HTR7(3363)

Description

Application

SB-269970 hydrochloride has been used to study the effect of different endotype combination on the activity of the 5-hydroxytryptamine receptor of tall fescue alkaloids. It has also been used to inhibit dopamine receptor signaling, in order to study its role in early hemocyte activation.

SB-269970 was used to study the role of 5-HT₇ receptors in serotonin-induced hypothermia in rodents.⁶

Biochem/physiol Actions

SB-269970 is an anti-psychotic agent that shows high affinity for 5-HT₇ receptors. It may be effective in treating cognitive disabilities and schizophrenia-like deficits.⁴ SB-269970 desensitizes and decreases the excitatory effects of 5-HT₇ receptors in rat hippocampus.⁵

Selective 5-HT₇ serotonin receptor antagonist.

Legal Information

Sold with the permission of GlaxoSmithKline Pharmaceuticals

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves