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Key Documents

RAB1038

Sigma-Aldrich

Human ECM-1 ELISA Kit

for cell culture supernatants, plasma, and serum samples

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About This Item

UNSPSC Code:
41116158
NACRES:
NA.32

species reactivity

human

packaging

kit of 96 wells (12 strips x 8 wells)

technique(s)

ELISA: suitable

input

sample type plasma
sample type cell culture supernatant(s)
sample type serum sample(s)

assay range

inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 24 pg/ml

detection method

colorimetric

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... ECM1(1893)

General description

Extracellular matrix protein 1 (ECM1) is a glycoprotein. It is expressed in skin and other tissues. The gene encoding this protein is localized on human chromosome 1q21.2.
This ELISA antibody pair detects Human Extracellular Matrix Protein 1 (ECM1)

Application

For research use only. Not for use in diagnostic procedures.
Please refer to the attached Protocolfor details.

Biochem/physiol Actions

Extracellular matrix protein 1 (ECM1) has a role in cell proliferation, mineralization and angiogenesis. The protein has been shown to have a role in cancer invasion and progression. It is associated with hepatocellular carcinoma. Mutations in the ECM1 gene have been linked to lipoid proteinosis. The protein also promotes the Warburg effect, which is an oncogenic switch that allows cancerous cells to take in more glucose than non-cancerous cells.

Other Notes

A sample Certificate of Analysis is available for this product. Please type the word sample in the text box provided for lot number.

Pictograms

Corrosion
GHS05

Signal Word

Warning

Hazard Statements

H290

Precautionary Statements

P234 - P390

Hazard Classifications

Met. Corr. 1

Storage Class Code

8A - Combustible corrosive hazardous materials

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Megan E Grund et al.
PloS one, 15(11), e0242593-e0242593 (2020-11-24)
Bacterial efflux pumps are an important pathogenicity trait because they extrude a variety of xenobiotics. Our laboratory previously identified in silico Burkholderia collagen-like protein 8 (Bucl8) in the hazardous pathogens Burkholderia pseudomallei and Burkholderia mallei. We hypothesize that Bucl8, which
Extracellular matrix protein 1 gene (ECM1) mutations in nine Iranian families with lipoid proteinosis
Izadi F, et al.
The Indian Journal of Medical Research, 143(3), 303-303 (2016)
ECM1 promotes migration and invasion of hepatocellular carcinoma by inducing epithelial-mesenchymal transition
Chen H, et al.
World Journal of Surgical Oncology, 14(1), 195-195 (2016)
Danielle E Baranova et al.
PloS one, 13(1), e0190026-e0190026 (2018-01-03)
Vibrio cholerae O1 is one of two serogroups responsible for epidemic cholera, a severe watery diarrhea that occurs after the bacterium colonizes the human small intestine and secretes a potent ADP-ribosylating toxin. Immunity to cholera is associated with intestinal anti-lipopolysaccharide
Alee Choi et al.
International journal of molecular sciences, 21(17) (2020-09-03)
Extracellular matrix (ECM) components play an important role in maintaining skeletal muscle function, but excessive accumulation of ECM components interferes with skeletal muscle regeneration after injury, eventually inducing fibrosis. Increased oxidative stress level caused by dystrophin deficiency is a key
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