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PVP1

Sigma-Aldrich

Poly(vinylpyrrolidone)–Iodine complex

Synonym(s):

PVP-Iodine, Polyvinylpyrrolidone Iodine, PVP-I, Povadyne® antiseptic

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About This Item

CAS Number:
25655-41-8
MDL number:
MFCD00084483
UNSPSC Code:
51102829
PubChem Substance ID:
24899316
NACRES:
NA.85

form

powder

solubility

H2O: 100 mg/mL

antibiotic activity spectrum

Gram-negative bacteria
Gram-positive bacteria
fungi
parasites
viruses
yeast

Mode of action

protein synthesis | interferes

SMILES string

II.C=CN1CCCC1=O

InChI

1S/C6H9NO.I2/c1-2-7-5-3-4-6(7)8;1-2/h2H,1,3-5H2;

InChI key

CPKVUHPKYQGHMW-UHFFFAOYSA-N

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Application

Poly(vinylpyrrolidone)–Iodine complex, or PVP-I, has been used to study microbial decontamination of human donor eyes and the inactivation of infectious hematopoietic necrosis virus.

Biochem/physiol Actions

PVP-1 is used as a slow iodine release formulation that iodinates lipids and oxidizes cell compounds such as tyrosine sidechains. It is used as a carbon nanotube coating agent to improve water solubility.

Other Notes

An iodophor; "tamed iodine."
Keep container tightly closed in a dry and well-ventilated place.

Legal Information

Povadyne is a registered trademark of National Patent Development Corp.

Pictograms

CorrosionEnvironment
GHS05,GHS09

Signal Word

Danger

Hazard Statements

H315,H318,H411

Hazard Classifications

Aquatic Chronic 2 - Eye Dam. 1 - Skin Irrit. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

>212.0 °F - Not applicable

Flash Point(C)

> 100 °C - Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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Mitchell S Fineman et al.
Retina (Philadelphia, Pa.), 33(9), 1968-1970 (2013-04-24)
To describe an alternative technique for avoiding contact with the lids and eyelashes without the use of a metal lid speculum along with the results in clinical practice. Retrospective review of the medical records of all patients undergoing intravitreal injections
Philippe Seguin et al.
Critical care medicine, 42(1), 1-8 (2013-10-10)
To evaluate the efficacy and safety of oral care with povidone-iodine on the occurrence of ventilator-associated pneumonia in a high-risk population. A multicenter, placebo-controlled, randomized, double-blind, two-parallel-group trial performed between May 2008 and May 2011. Six ICUs in France. One
Pracha Nuntnarumit et al.
Infection control and hospital epidemiology, 34(4), 430-432 (2013-03-08)
We conducted a randomized controlled trial in neonates with birth weight greater than or equal to 1,500 g that compared 1% aqueous chlorhexidine gluconate (CHG) with 10% povidone-iodine (PI) as a topical antiseptic. We found 1% CHG to be more
Lina Du et al.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, 20(6), 904-910 (2012-11-01)
In this study, a multifunctional in situ-forming hydrogel (MISG) was prepared as a wound dressing designed to stop bleeding, inhibit inflammation, relieve pain, and improve healing. A mixture of poloxamers 407 and 188 was used for the matrix of the
A Tuna et al.
Australian dental journal, 57(4), 435-439 (2012-11-29)
The aim of this pilot study was to evaluate the effects of mouthrinses containing 7.5% povidone iodine and 0.2% chlorhexidine on bacteraemia following impacted third molar surgery. Thirty-four patients were enrolled in this study. Patients in the first group were
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