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P8925

Sigma-Aldrich

Octaethylene glycol monododecyl ether

≥98% (GC)

Synonym(s):

C12E8, Dodecyl octaethylene glycol ether, Dodecyloctaglycol, Polyoxyethylene (8) lauryl ether

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About This Item

Linear Formula:
CH3(CH2)11(OCH2CH2)8OH
CAS Number:
3055-98-9
Molecular Weight:
538.75
Beilstein:
1893466
MDL number:
MFCD00043234
UNSPSC Code:
12161900
PubChem Substance ID:
24898996
NACRES:
NA.25

description

non-ionic

Assay

≥98% (GC)

form

solid

mol wt

average mol wt 66,000

aggregation number

123

CMC

0.11

SMILES string

CCCCCCCCCCCCOCCOCCOCCOCCOCCOCCOCCOCCO

InChI

1S/C28H58O9/c1-2-3-4-5-6-7-8-9-10-11-13-30-15-17-32-19-21-34-23-25-36-27-28-37-26-24-35-22-20-33-18-16-31-14-12-29/h29H,2-28H2,1H3

InChI key

YYELLDKEOUKVIQ-UHFFFAOYSA-N

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General description

Octaethylene glycol monododecyl ether is a nonionic detergent.

Application

Octaethylene glycol monododecyl ether has been used in a study to assess intestinal sodium transport mechanisms. It has also been used in a study to investigate interactions between dyes and surfactants in inkjet ink used for textiles.
Detergent used for the study of membrane proteins in a native-like state, e.g. ATPase. Used in a mixed micellar assay for lipoxygenase acting at neutral pH and for functional reconstitution of influenza virus envelopes.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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G C Troiano et al.
Biophysical journal, 75(2), 880-888 (1998-07-24)
The effects of a nonionic surfactant, octaethyleneglycol mono n-dodecyl ether (C12E8), on the electroporation of planar bilayer lipid membranes made of the synthetic lipid 1-pamitoyl 2-oleoyl phosphatidylcholine (POPC), was studied. High-amplitude ( approximately 100-450 mV) rectangular voltage pulses were used
[Relationship between activity and tetraprotomeric structure of ion-transporting ATPases].
Kazuhiro Abe et al.
Seikagaku. The Journal of Japanese Biochemical Society, 79(6), 527-534 (2007-08-01)
Cédric Montigny et al.
Biochemical and biophysical research communications, 391(1), 1067-1069 (2009-12-17)
Many membrane proteins become labile when they are solubilized by detergent. Here we show that the presence of high concentrations of glycyl betaine stabilizes one of these proteins, the sarcoplasmic reticulum Ca(2+)-ATPase (SERCA1a), solubilized with nonionic detergents like n-dodecyl beta-d-maltopyranoside
Hiren Patel et al.
Biophysical chemistry, 150(1-3), 119-128 (2010-04-27)
We have studied the effect of two cosolvents, urea and glycerol, on the association and interactions of a surfactant, octaethyleneglycol dodecyl ether (C(12)EO(8)) and a phospholipid (POPC). We have measured the CMC, the partition coefficient, the effective mole fractions X(e)(sat)
L Tortech et al.
Biochimica et biophysica acta, 1514(1), 76-86 (2001-08-22)
Many attempts have been made to rationalize the use of detergents for membrane protein studies [J. Biol. Chem. 264 (1989) 4907]. The barrier properties of the detergent headgroup may be one parameter critically involved in protein protection. In this paper
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