P7936

Phosphocreatine disodium salt hydrate

≥97%

• Synonym(s): Creatine phosphate disodium salt, N-(Imino[phosphonoamino]methyl)-N-methylglycine
• Linear Formula: C₄H₈N₃O₅PNa₂ · x H₂O
• CAS Number: 19333-65-4
• Molecular Weight: 255.08 (anhydrous basis)
• EC Number: 213-074-6
• MDL number: MFCD00150191
• UNSPSC Code: 12352204
• PubChem Substance ID: 24898895
• NACRES: NA.32

Properties

• product name: Phosphocreatine disodium salt hydrate, ≥97%
• Assay: ≥97%
• form: powder
• impurities: ≤0.02% free creatine
• color: white
• solubility: water: 50 mg/mL, clear, colorless
• storage temp.: −20°C
• SMILES string: O.[Na+].[Na+].CN(CC(O)=O)C(=N)NP([O-])([O-])=O
• InChI: 1S/C4H10N3O5P.2Na.H2O/c1-7(2-3(8)9)4(5)6-13(10,11)12;;;/h2H2,1H3,(H,8,9)(H4,5,6,10,11,12);;;1H2/q;2*+1;/p-2
• InChI key: KZVYPOKBYRXZKS-UHFFFAOYSA-L

Description

Application

Phosphocreatine disodium salt hydrate has been used:

• as a component: of Xenopus buffer (XB) buffer to remove the membrane-bound proteins
• of M5⁺ buffer to perform polarized total internal reflection fluorescence (polTIRF) experiments
• of ATP regenerating system for 7-nitro-2-1,3-benzoxadiazol-4-yl phospholipid(NBD-PL) translocation assay

Biochem/physiol Actions

Phosphocreatine disodium salt hydrate is useful to study nasopharyngeal carcinoma cells and induced temporary cardiac arrest. It also evaluate the effects of adenosine A(2A) receptor modulation in the nucleus accumbens on cocaine seeking in rats.

Phosphocreatine is widely known for its quickest form of regeneration using enzyme creatine kinase. It functions as a temporal energy buffer. Phosphocreatine is present in muscle tissues and plays a major role in maintaining energy homeostasis in muscle cells.

Phosphocreatine, a high-energy phosphate reservoir in vertebrate and some invertebrate muscles, provides phosphate for ADP-ATP conversion.

Preparation Note

Prepared enzymatically

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves