M0896

MPTP Hydrochloride

≥98% (AgNO3), powder, dopaminergic neurotoxin

• Synonym(s): MPTP HCl, Pyridine, 1,2,3,6-tetrahydro-1-methyl-4-phenyl-, hydrochloride, MPTP hydrochloride
• Empirical Formula (Hill Notation): C₁₂H₁₅N · HCl
• CAS Number: 23007-85-4
• Molecular Weight: 209.72
• Beilstein: 3707312
• MDL number: MFCD00012790
• UNSPSC Code: 12352200
• PubChem Substance ID: 24896578
• NACRES: NA.77

Properties

• product name: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride, powder
• form: powder
• drug control: kontrollierte Droge in Deutschland
• color: white to off-white
• SMILES string: Cl[H].CN1CCC(=CC1)c2ccccc2
• InChI: 1S/C12H15N.ClH/c1-13-9-7-12(8-10-13)11-5-3-2-4-6-11;/h2-7H,8-10H2,1H3;1H
• InChI key: KOWJANGMTAZWDT-UHFFFAOYSA-N

Description

General description

MPTP shows its effects by causing inflammation, excitotoxicity, mitochondrial apoptosis, formation of inclusion bodies, and oxidative stress that leads to dopaminergic neuronal damage in the striatum and substantia nigra. In dopaminergic neurons, MPTP blocks the mitochondrial complex I which leads to mitochondrial dysfunction.

Application

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride has been used to induce Parkinson′s disease (PD) in animal models:

• to study the effect of docosahexaenoic acid on the apelin distribution of the nervous system
• to study the behavioral impairments correlated to neurochemical deficits
• to study the effects of treadmill exercise on neuroprotection and neuroinflammation

MPTP has been used to study its effects on microglial innate immune memory. It has also been used to study the protective effects of phenylpropionamides in Pakinson’s diseased mice models.

Biochem/physiol Actions

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is a piperidine derivative and dopaminergic neurotoxin, useful in neurological research. MPTP is metabolized to 1-methyl-4-phenylpyridine (MPP+), which in turn can cause free radical production in vivo and lead to oxidative stress. Thus MPP+ is generally acknowledged as the active metabolite of MPTP. MPTP is widely used in in vivo research studies as a model for Parkinsonism. A review describes the application of MPTP in studies related to programmed cell death in neurogenerative diseases.

Dopaminergic neurotoxin.

Warning

Reportedly causes a severe and irreversible Parkinsonian condition in humans and monkeys.

Other Notes

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Safety Information

• Pictograms: GHS06,GHS08
• Signal Word: Danger
• Hazard Statements: H301,H370
• Precautionary Statements: P260 - P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral - STOT SE 1
• Target Organs: Nervous system
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3