I9910

Ibutilide hemifumarate salt

≥98% (HPLC)

• Synonym(s): (±)-N-[4-[4-(Ethylheptylamino)-1-hydroxybutyl]phenyl]-methanesulfonamide hemifumarate salt, Corvert
• Empirical Formula (Hill Notation): C₂₀H₃₆N₂O₃S · 0.5C₄H₄O₄
• CAS Number: 122647-32-9
• Molecular Weight: 442.61
• MDL number: MFCD01715410
• UNSPSC Code: 12352200
• PubChem Substance ID: 329815470
• NACRES: NA.77

Properties

• Assay: ≥98% (HPLC)
• form: solid
• color: off-white to tan
• solubility: H₂O: >20 mg/mL
• storage temp.: room temp
• SMILES string: OC(=O)\C=C\C(O)=O.CCCCCCCN(CC)CCCC(O)c1ccc(NS(C)(=O)=O)cc1.CCCCCCCN(CC)CCCC(O)c2ccc(NS(C)(=O)=O)cc2
• InChI: 1S/2C20H36N2O3S.C4H4O4/c2*1-4-6-7-8-9-16-22(5-2)17-10-11-20(23)18-12-14-19(15-13-18)21-26(3,24)25;5-3(6)1-2-4(7)8/h2*12-15,20-21,23H,4-11,16-17H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;;2-1+
• InChI key: PCIOHQNIRPWFMV-WXXKFALUSA-N
• Gene Information: human ... KCNH2(3757)

Description

Biochem/physiol Actions

Ibutilide hemifumarate salt is considered a new generation "pure" Class III antiarrhythmic agent. Ibutilide binds to and alters the activity of hERG potassium channels, delayed inward rectifier potassium (IKr) channels and L-type (dihydropyridine sensitive) calcium channels.

Features and Benefits

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• Pictograms: GHS08,GHS07
• Signal Word: Warning
• Hazard Statements: H302,H361d
• Precautionary Statements: P202 - P264 - P270 - P280 - P301 + P312 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Repr. 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable