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I2778

Sigma-Aldrich

IL-1α human

≥98% (SDS-PAGE and HPLC), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

Synonym(s):

IL-1α, hIL-1α., Interleukin-1α human, Lymphocyte activating factor

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About This Item

MDL number:
UNSPSC Code:
12352202
NACRES:
NA.77

product name

Interleukin-1α human, IL-1α, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

biological source

human

Quality Level

recombinant

expressed in E. coli

Assay

≥98% (SDS-PAGE and HPLC)

form

lyophilized powder

quality

endotoxin tested

mol wt

~17 kDa

packaging

pkg of 2 and 10 μg

technique(s)

cell culture | mammalian: suitable

UniProt accession no.

storage temp.

−20°C

Gene Information

human ... IL1A(3552)

General description

Interleukin-1α (IL-1α) is a cytokine that belongs to the interleukin-1 (IL-1) family. It is located intracellularly in hematopoietic and non-hematopoietic cells. IL-1α gene is located on the human chromosome at 2q14.1.

Application

Interleukin-1α (IL-1α) has been used:
  • to study its effects on human colorectal adenocarcinoma cells
  • to stimulate primary human fetal retinal pigment epithelium (hfRPE) cells
  • to pre-stimulate human THP-1 monocytes

Biochem/physiol Actions

Interleukin-1α (IL-1α) plays a crucial role in inflammation during cell necrosis. It also regulates the recruitment of interleukin-1β (IL-1β), neutrophils, chemokines, and other cytokines at the site of injury. IL-1α exhibits a dual function of binding to its cell surface receptor as well as chromatin.

Physical form

Lyophilized from 0.2 μm filtered 10 mM sodium phosphate , pH 8.0, plus 50 mm NaCl and 50 μg bovine serum albumin (BSA) per μg cytokine.

Analysis Note

The proliferative activity of human IL-1α is tested in culture using the murine cell line D10S.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Precautionary Statements

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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