G4626

L-Glutathione oxidized disodium salt

≥98%, suitable for HPLC

• Synonym(s): GSSG
• Empirical Formula (Hill Notation): C₂₀H₃₀N₆Na₂O₁₂S₂
• CAS Number: 103239-24-3
• Molecular Weight: 656.59
• Beilstein: 6265389
• MDL number: MFCD00148894
• UNSPSC Code: 12352209
• PubChem Substance ID: 24895179
• NACRES: NA.26

Properties

• product name: L-Glutathione oxidized disodium salt, ≥98%, powder
• Quality Level: 200
• Assay: ≥98%
• form: powder
• technique(s): HPLC: suitable
• impurities: ethanol, essentially free
• color: white to off-white
• storage temp.: −20°C
• SMILES string: [Na+].[Na+].N[C@@H](CCC(=O)N[C@@H](CSSC[C@H](NC(=O)CC[C@H](N)C([O-])=O)C(=O)NCC(O)=O)C(=O)NCC([O-])=O)C(O)=O
• InChI: 1S/C20H32N6O12S2.2Na/c21-9(19(35)36)1-3-13(27)25-11(17(33)23-5-15(29)30)7-39-40-8-12(18(34)24-6-16(31)32)26-14(28)4-2-10(22)20(37)38;;/h9-12H,1-8,21-22H2,(H,23,33)(H,24,34)(H,25,27)(H,26,28)(H,29,30)(H,31,32)(H,35,36)(H,37,38);;/q;2*+1/p-2/t9-,10-,11-,12-;;/m0../s1
• InChI key: DRFILBXQKYDTFW-JIWRMXRASA-L

Description

Amino Acid Sequence

(γ-Glu-Cys-Gly) (γ-Glu-Cys-Gly) [Disulfide bridge: 2_a-2_b]

Application

L-Glutathione oxidized disodium salt has been used in 5,5′-dithiobis-(2-nitrobenzoic acid) (DTNB)/glutathione reductase enzyme recycling method to determine plasma or tissue glutathione levels. It has also been used in NADPH-dependent glutathione disulfide reduction assay.

Biochem/physiol Actions

Oxidized L-glutathione is frequently measured in vivo as an indicator of oxidative stress. Oxidized L-Glutathione may be converted to L-glutathione by various reducing systems.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves