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B5683

Sigma-Aldrich

Betaxolol hydrochloride

>98% (HPLC)

Synonym(s):

SL 75212

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About This Item

Empirical Formula (Hill Notation):
C18H29NO3 · HCl
CAS Number:
63659-19-8
Molecular Weight:
343.89
EC Number:
264-384-3
MDL number:
MFCD00242959
UNSPSC Code:
12352200
PubChem Substance ID:
24278274
NACRES:
NA.77

Assay

>98% (HPLC)

form

solid

storage condition

desiccated

color

white

solubility

H2O: soluble 36 mg/mL

originator

Alcon

SMILES string

Cl[H].CC(C)NCC(O)COc1ccc(CCOCC2CC2)cc1

InChI

1S/C18H29NO3.ClH/c1-14(2)19-11-17(20)13-22-18-7-5-15(6-8-18)9-10-21-12-16-3-4-16;/h5-8,14,16-17,19-20H,3-4,9-13H2,1-2H3;1H

InChI key

CHDPSNLJFOQTRK-UHFFFAOYSA-N

Gene Information

human ... ADRB1(153)

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Application

Betaxolol hydrochloride has been used as a β1 blocking agent:
  • for the preparation of crystals of (R,S)-betaxolol (BE-IV).
  • to treat mammalian cells prior cell stimulation experiments.
  • to study the solid structure of metoprolol.

Biochem/physiol Actions

Betaxolol hydrochloride has the ability to block calcium channels. Betaxolol is a selective β1 adrenoreceptor antagonist. It has neuroprotective effects on retinal neurons.

Features and Benefits

This compound is featured on the β-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Alcon. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Precautionary Statements

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Investigating Differences and Similarities between Betaxolol Polymorphs
Rossi P, et al.
Crystals, 9(10), 509-509 (2019)
Yi Huang et al.
International journal of nanomedicine, 12, 1731-1745 (2017-03-11)
As a novel ion-exchange carrier with high surface area and excellent exchangeability, montmorillonite (Mt) was intercalated with betaxolol hydrochloride (BH) to form a nanocomposite and then encapsulated by liposomes (Mt-BH-LPs) for an ophthalmic drug-delivery system. The Mt-BH and Mt-BH-LPs were
João Canotilho et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 76(3-4), 395-400 (2010-04-27)
Betaxolol is a selective beta(1) receptor blocker used in the treatment of hypertension and glaucoma. A study of the betaxolol structure based on infrared spectroscopy and natural bond orbital (NBO) theory is the main aim of the present research. FTIR
Ana Franky Carvalho et al.
Neuroscience letters, 500(1), 82-85 (2011-06-23)
The cannabinoid system is known to interact with a variety of neuromodulators in the central nervous system and impacts diverse behaviors. Previous studies have demonstrated that limbic norepinephrine is a critical determinant in the behavioral expression of cannabinoid-induced aversion. The
Patrizia Rossi et al.
Acta crystallographica. Section C, Structural chemistry, 75(Pt 2), 87-96 (2019-02-06)
Metoprolol {systematic name: (RS)-1-isopropylamino-3-[4-(2-methoxyethyl)phenoxy]propan-2-ol}, C15H25NO3, is a cardioselective β1-adrenergic blocking agent that shares part of its molecular skeleton with a large number of other β-blockers. Results from its solid-state characterization by single-crystal and variable-temperature powder X-ray diffraction and differential scanning
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