A8861

Aceclofenac

≥98% (HPLC)

• Synonym(s): 2-[(2,6-Dichlorophenyl)amino]benzeneacetic acid carboxymethyl ester;
• Empirical Formula (Hill Notation): C₁₆H₁₃Cl₂NO₄
• CAS Number: 89796-99-6
• Molecular Weight: 354.18
• MDL number: MFCD00864296
• UNSPSC Code: 12352200
• PubChem Substance ID: 329771021
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• color: off-white to light tan
• solubility: DMSO: ≥20 mg/mL
• storage temp.: room temp
• SMILES string: OC(=O)COC(=O)Cc1ccccc1Nc2c(Cl)cccc2Cl
• InChI: 1S/C16H13Cl2NO4/c17-11-5-3-6-12(18)16(11)19-13-7-2-1-4-10(13)8-15(22)23-9-14(20)21/h1-7,19H,8-9H2,(H,20,21)
• InChI key: MNIPYSSQXLZQLJ-UHFFFAOYSA-N
• Gene Information: human ... PTGS2(5743)

Description

Application

Aceclofenac (ACE) has been used as an internal standard in the in vivo blood-brain barrier assay. It has also been used to study the interaction of ACE with bovine serum albumin (BSA) by using spectroscopic techniques in combination with computational methods.

Biochem/physiol Actions

Aceclofenac is a phenyl acetic acid derivative used for treating symptoms like swelling, tenderness, and stiffness due to muscle-skeletal and bone-related diseases (rheumatoid arthritis, juvenile arthritis, osteoarthritis, and acute gouty arthritis). This compound shows analgesic and antipyretic properties. Aceclofenac suppresses prostaglandin biosynthesis.

Non-steroidal, anti-inflammatory drug (NSAID), with selectivity for COX-2 over COX-1.

Safety Information

• Pictograms: GHS06,GHS09
• Signal Word: Danger
• Hazard Statements: H301,H319,H410
• Precautionary Statements: P264 - P273 - P280 - P301 + P310 - P305 + P351 + P338 - P337 + P313
• Hazard Classifications: Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable