52423

Dextran sulfate sodium salt from Leuconostoc spp.

low sulfate content, M_r ~40,000

• CAS Number: 9011-18-1
• MDL number: MFCD00081551
• UNSPSC Code: 12352201
• NACRES: NA.25

Properties

• biological source: (Leuconostoc spp)
• Quality Level: 100
• form: powder
• quality: low sulfate content
• mol wt: M_r ~40,000
• composition: Sulfur Content, 8-13%
• loss: ≤10% loss on drying
• color: white to off-white
• useful pH range: 6.0-8 (10 g/L)
• solubility: H₂O: 100 mg/mL, clear, colorless to faintly greenish-yellow
• storage temp.: room temp

Description

General description

Dextran is a polymer of anhydroglucose. It is composed of approximately 95% alpha-D-(166) linkages. The remaining (163) linkages account for the branching of dextran.

Application

Dextran sulfate increases binding of epithelial cells and lymphocytes to extracellular matrix proteins including fibronectin and laminin. In addition, dextran sulfate altered expreβion of cell surface receptors integrins.

Dextran sulfate is routinely used for the selective precipitation of lipoproteins, probe hybridization membrane-immobilized DNA, the release of DNA from DNA-histone complexes, and the inhibition of RNA binding to ribosomes.

Preparation Note

Sigma dextrans are derived from Leuconostoc mesenteroides.

Other Notes

To gain a comprehensive understanding of our extensive range of Dextrans for your research, we encourage you to visit our Carbohydrates Category page.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable