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30906

Sigma-Aldrich

Castor Oil, Ethoxylated

Synonym(s):

Cremophor® ELP, ELP, PEG-35 castor oil, Polyoxyl-35 castor oil

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About This Item

CAS Number:
61791-12-6
MDL number:
MFCD00130879
UNSPSC Code:
12161900
NACRES:
NA.25

description

non-ionic

form

paste

impurities

alkalinity, complies
≤ acetic acid (≤0.5 g/100g (%) verfied on random samples only)
≤0.1% oleic acid
≤0.1% palmitic acid
≤0.2% sulfated ash (verfied on random samples only)
≤0.20% ricinoleic acid
≤0.5% water
≤1 ppm ethylene oxide (verfied on random samples only)
≤1.0% free fatty acids
≤10 ppm dioxan (verfied on random samples only)
≤10 ppm heavy metals (verfied on random samples only)
≤620 ppm diethylene glycol (verfied on random samples only)
≤620 ppm ethylene glycol (verfied on random samples only)

ign. residue

≤0.2%

pH

5.0-7.0 (1 g/10 mL in H2O)

viscosity

600-750 mPa.s(25 °C)

acid value

≤2.0 mg KOH/g

hydroxyl value

65‑78 mg KOH/g

iodine value

25‑35 g/100g

saponification value

65‑70 mg KOH/g

cation traces

K: ≤15 ppm

InChI

1S/C4H7Cl2NO2/c5-1-3(2-6)9-4(7)8/h3H,1-2H2,(H2,7,8)

InChI key

JMNCUXPHXKHBPY-UHFFFAOYSA-N

Application

Castor Oil, Ethoxylated is used to emulsify and solubilize oils and other water-insoluble substances. Similar to Castor Oil, Ethoxylated but with lower water content and differences in viscosity.

Analysis Note

relative density D (25/25) 1.05-1.06

Legal Information

Cremophor is a registered trademark of BASF SE

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

494.6 °F - Not applicable

Flash Point(C)

257 °C - Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Allergic contact dermatitis to polyethylene glycol-7 hydrogenated castor oil.
M Kalavala et al.
Contact dermatitis, 56(5), 287-288 (2007-04-20)
K Itoh et al.
International journal of pharmaceutics, 246(1-2), 75-83 (2002-09-25)
The optimized formulation of N-4472, N-[2-(3,5-di-tert-butyl-4-hydroxyphenethyl)-4,6-difluorophenyl]-N'-[4-(N-benzylpiperidyl)] urea, which was a poorly water-soluble drug, was developed by utilizing the complexation between N-4472 and L-ascorbic acid (VC). It was found that the formulation with Gelucire((R)) 44/14, HCO-60((R)) and sodium dodecyl sulfate provided
Nuhad K Ibrahim et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 8(5), 1038-1044 (2002-05-15)
ABI-007 is a novel Cremophor-free, protein-stabilized, nanoparticle formulation of paclitaxel. The absence of Cremophor EL may permit ABI-007 to be administered without the premedications used routinely for the prevention of hypersensitivity reactions. Furthermore, this novel formulation permits a higher paclitaxel
Yukako Ito et al.
Journal of drug targeting, 13(6), 383-390 (2005-11-10)
Interferon alpha (IFN-alpha), patch preparations composed of three layers, water-insoluble backing layer, drug containing layer with absorption enhancer and surface layer containing pH-dependent polymer were prepared. As absorption enhancer, three surfactants, Gelucire44/14 (Lauroyl macrogol-32 glycerides), Labrasol (Caprylocaproyl macrogol-8 glycerides) and
Yun-Seok Rhee et al.
Archives of pharmacal research, 30(1), 114-123 (2007-03-03)
The aim of this study was to develop an aqueous parenteral formulation containing itraconazole (ITZ) using an o/w microemulsion system. A mixture of benzyl alcohol and medium chain triglyceride (3/1) was chosen as the oil phase. Pseudoternary phase diagrams of
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