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Key Documents

Y0000507

Chlorpromazine impurity A

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

Chlorpromazine sulfoxide, 3-(2-Chloro-10H-phenothiazin-10-yl)-N,N-dimethylpropan-1- amine S-oxide

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About This Item

Empirical Formula (Hill Notation):
C17H19ClN2OS
CAS Number:
969-99-3
Molecular Weight:
334.86
UNSPSC Code:
41116107
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

chlorpromazine

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

InChI

1S/C17H19ClN2OS/c1-19(2)10-5-11-20-14-6-3-4-7-16(14)22(21)17-9-8-13(18)12-15(17)20/h3-4,6-9,12H,5,10-11H2,1-2H3

InChI key

QEPPAOXKZOTMPM-UHFFFAOYSA-N

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Chlorpromazine impurity A EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Y Miyamoto et al.
The Journal of pharmacology and experimental therapeutics, 245(3), 823-828 (1988-06-01)
We investigated the effects of various phenothiazines on the Na+-H+ exchanger in brush-border membrane vesicles isolated from the proximal small intestine of the rabbit. The Na+-H+ exchanger activity was assayed by measuring the dimethylamiloride-sensitive Na+ uptake into these vesicles in
Binding of 125I-calmodulin to platelet alpha-granules.
S Grinstein et al.
FEBS letters, 140(1), 49-52 (1982-04-05)
P P Kelder et al.
Biochemical pharmacology, 38(20), 3593-3599 (1989-10-15)
The possible role of hemoglobin in the sulfoxidation of chlorpromazine is still a controversial subject. Therefore this sulfoxidation was investigated with purified oxyhemoglobin and methemoglobin under various conditions: (i) in phosphate buffer pH 6.5; (ii) in monooxygenase mimicking systems with
P K Yeung et al.
Journal of pharmaceutical sciences, 76(10), 803-808 (1987-10-01)
Antibodies specific to chlorpromazine N-oxide (CPZNO) were produced in rabbits immunized with a hapten-bovine serum albumin conjugate, which was prepared by linking the 7-position of the phenothiazine ring of the metabolite to the protein via a 4-carbon bridge. An extraction
Determination of chlorpromazine and its sulphoxide in pharmaceutical dosage forms by third-order derivative ultraviolet spectroscopy.
A A Fasanmade et al.
The Analyst, 110(9), 1117-1124 (1985-09-01)
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