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Key Documents

Y0000317

Mesna impurity D

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

2,2′-Dithiobisethanesulfonic acid, 2,2′-(Disulphanediyl)bis(ethanesulphonic acid)

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About This Item

Empirical Formula (Hill Notation):
C4H10O6S4
CAS Number:
45127-11-5
Molecular Weight:
282.38
UNSPSC Code:
41116107
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

mesna

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

[Na+].[Na+].[S](=O)(=O)([O-])CCSSCC[S](=O)(=O)[O-]

InChI

1S/C4H10O6S4.2Na/c5-13(6,7)3-1-11-12-2-4-14(8,9)10;;/h1-4H2,(H,5,6,7)(H,8,9,10);;/q;2*+1/p-2

InChI key

KQYGMURBTJPBPQ-UHFFFAOYSA-L

Related Categories

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Mesna impurity D EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Maartje M C Bastings et al.
BMC biotechnology, 8, 76-76 (2008-10-03)
Expression systems based on self-cleavable intein domains allow the generation of recombinant proteins with a C-terminal thioester. This uniquely reactive C-terminus can be used in native chemical ligation reactions to introduce synthetic groups or to immobilize proteins on surfaces and
Lakshmi Pendyala et al.
Cancer chemotherapy and pharmacology, 51(5), 376-384 (2003-04-19)
BNP7787 (disodium 2,2'-dithio-bis-ethane sulfonate) was evaluated in a phase I clinical trial with paclitaxel and cisplatin to assess the safety and potential efficacy for preventing or reducing cisplatin- and paclitaxel-induced toxicities. During this trial the effects of BNP7787 administration on
Antonius A Miller et al.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 3(10), 1159-1165 (2008-10-02)
We investigated dose-dense docetaxel and cisplatin in patients with measurable non-small cell lung cancer in a randomized phase II study without [A] or with [B] a putative chemoprotective agent, BNP7787. Chemotherapy-naive patients with stage IIIB (effusion) or IV, performance status
Supercomputer-designed drug protects against chemotherapy toxicity.
K Senior
The Lancet. Oncology, 1, 198-198 (2002-03-22)
Miranda Verschraagen et al.
Cancer chemotherapy and pharmacology, 51(6), 525-529 (2003-05-17)
BNP7787 (2',2'-dithio-bis-ethane sulfonate sodium) is a novel protector against cisplatin-induced toxicities. The pharmacokinetics of BNP7787 and its metabolite mesna were investigated in plasma and ascites of a cancer patient. We also evaluated potential pharmacokinetic interactions between BNP7787 and cisplatin. BNP7787
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