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I1762

Supelco

Isoxicam

analytical standard

Synonym(s):

4-Hydroxy-2-methyl-N-5-methyl-3-isoxolyl-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxide

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About This Item

Empirical Formula (Hill Notation):
C14H13N3O5S
CAS Number:
34552-84-6
Molecular Weight:
335.34
EC Number:
252-084-5
MDL number:
MFCD00079374
UNSPSC Code:
41116107
PubChem Substance ID:
329815356
NACRES:
NA.24

grade

analytical standard

Quality Level

200

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

format

neat

SMILES string

CN1C(C(=O)Nc2cc(C)on2)=C(O)c3ccccc3S1(=O)=O

InChI

1S/C14H13N3O5S/c1-8-7-11(16-22-8)15-14(19)12-13(18)9-5-3-4-6-10(9)23(20,21)17(12)2/h3-7,18H,1-2H3,(H,15,16,19)

InChI key

YYUAYBYLJSNDCX-UHFFFAOYSA-N

Gene Information

human ... PTGS1(5742) , PTGS2(5743)

General description

Isoxicam is a long acting anti-inflammatory agent belonging to the oxicam group, and helps in relieving the symptoms of degenerative joint disease and rheumatoid arthritis. Its mode of action involves the ability to inhibit prostaglandin synthesis by suppressing the formation of cyclooxygenase and subsequent prostaglandin.

Application

Isoxicam may be used as an internal standard for the quantification of meloxicam in pharmaceutical preparations and as an analytical reference standard for the quantification of the analyte in biological samples using different analytical techniques.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
127F0579

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Oxicams: metabolic disposition in man and animals.
T F Woolf et al.
Drug metabolism reviews, 21(2), 255-276 (1989-01-01)
E M Grace et al.
Current medical research and opinion, 10(9), 580-591 (1987-01-01)
Nineteen patients, aged 60 years and over, with rheumatoid arthritis participated in a clinical trial to investigate the pharmacokinetics of isoxicam (a new non-steroidal anti-inflammatory drug) in this age group. The purpose of the study was to determine if the
M Tariq
Research communications in chemical pathology and pharmacology, 60(1), 19-25 (1988-04-01)
The protective effect of some novel nonsteroidal anti-inflammatory agents has been studied on the endotoxin (lipopolysaccharide B) shock induced mortality in mice and biochemical changes in rats. All the three compounds included in this report, namely isoxicam, fentiazac and ketoprofen
Flow injection chemiluminescence determination of isoxicam based on diperiodatoargentate (III)-fluorescein system in a micellar medium
Zhao F and Si H
Journal of Luminescence, 135(1), 259-264 (2013)
M Esquivel et al.
Clinical and investigative medicine. Medecine clinique et experimentale, 10(5), 363-367 (1987-09-01)
To determine the effect of liver dysfunction on the absorption and disposition of isoxicam, we administered a single oral dose of 200 mg to 8 patients with alcoholic cirrhosis, and followed the plasma concentration-time curve for 96 h. The calculated
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