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46794

Supelco

Sulfadimethoxine

VETRANAL®, analytical standard

Synonym(s):

4-Amino-N-(2,6-dimethoxy-4-pyrimidinyl)benzenesulfonamide

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About This Item

Empirical Formula (Hill Notation):
C12H14N4O4S
CAS Number:
122-11-2
Molecular Weight:
310.33
Beilstein:
306856
EC Number:
204-523-7
MDL number:
MFCD00057345
UNSPSC Code:
41116107
PubChem Substance ID:
329757244
NACRES:
NA.24

grade

analytical standard

Quality Level

200

Agency

EPA 1694

product line

VETRANAL®

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

antibiotic activity spectrum

Gram-negative bacteria
Gram-positive bacteria

application(s)

clinical testing

format

neat

Mode of action

DNA synthesis | interferes
enzyme | inhibits

storage temp.

2-8°C

SMILES string

COc1cc(NS(=O)(=O)c2ccc(N)cc2)nc(OC)n1

InChI

1S/C12H14N4O4S/c1-19-11-7-10(14-12(15-11)20-2)16-21(17,18)9-5-3-8(13)4-6-9/h3-7H,13H2,1-2H3,(H,14,15,16)

InChI key

ZZORFUFYDOWNEF-UHFFFAOYSA-N

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General description

Chemical structure: sulfonamide
Sulfadimethoxine is an long acting sulfonamide antibiotic, which finds applications in pen-held lobsters, Homarus americanus for treatment of gaffkemia.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Sulfadimethoxine may be used as a reference standard in the determination of sulfadimethoxine in eggs using high performance liquid chromatography (HPLC).

Legal Information

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Precautionary Statements

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCL9603
BCCL9553
BCCL5587
BCCK4645
BCCH3112

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Rapid high-performance liquid chromatographic determining technique of sulfamonomethoxine, sulfadimethoxine, and sulfaquinoxaline in eggs without use of organic solvents.
Analytica Chimica Acta null
Disposition of sulfadimethoxine in the lobster (Homarus americanus).
OMJ and GMB
Veterinary and Human Toxicology, 30, 36-40 (1988)
Photochemical fate of sulfadimethoxine in aquaculture waters.
Farusava N.
Environmental Science & Technology, 481(2), 255-259 (2003)
Alexandra Dheilly et al.
Antimicrobial agents and chemotherapy, 56(1), 189-196 (2011-10-12)
An experiment was conducted in animal facilities to compare the impacts of four avian colibacillosis treatments-oxytetracycline (OTC), trimethoprim-sulfadimethoxine (SXT), amoxicillin (AMX), or enrofloxacin (ENR)-on the susceptibility of Escherichia coli in broiler intestinal tracts. Birds were first orally inoculated with rifampin-resistant
Silvia Gazzin et al.
Pediatric research, 71(6), 653-660 (2012-02-18)
Few data exist on regional brain bilirubin content in the neonatal period when acute bilirubin-induced neurologic damage (BIND) may occur, and no information is available on regional brain expression of cytochrome P450 monooxygenases (Cyps) that oxidize bilirubin. Bilirubin content was
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