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00530580

Sennoside B

primary reference standard

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About This Item

Empirical Formula (Hill Notation):
C42H38O20
CAS Number:
128-57-4
Molecular Weight:
862.74
Beilstein:
5723747
EC Number:
204-895-0
MDL number:
MFCD00151528
UNSPSC Code:
85151701
PubChem Substance ID:
329747089
NACRES:
NA.24

grade

primary reference standard

shelf life

limited shelf life, expiry date on the label

manufacturer/tradename

HWI

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

SMILES string

OC[C@H]1O[C@@H](Oc2cccc3[C@@H]([C@H]4c5cccc(O[C@H]6O[C@H](CO)[C@@H](O)[C@H](O)[C@H]6O)c5C(=O)c7c(O)cc(cc47)C(O)=O)c8cc(cc(O)c8C(=O)c23)C(O)=O)[C@H](O)[C@@H](O)[C@@H]1O

InChI

1S/C42H38O20/c43-11-23-31(47)35(51)37(53)41(61-23)59-21-5-1-3-15-25(17-7-13(39(55)56)9-19(45)27(17)33(49)29(15)21)26-16-4-2-6-22(60-42-38(54)36(52)32(48)24(12-44)62-42)30(16)34(50)28-18(26)8-14(40(57)58)10-20(28)46/h1-10,23-26,31-32,35-38,41-48,51-54H,11-12H2,(H,55,56)(H,57,58)/t23-,24-,25-,26+,31-,32-,35+,36+,37-,38-,41-,42?/m1/s1

InChI key

IPQVTOJGNYVQEO-OVYIKYHGSA-N

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General description

Produced and qualified by HWI pharma services GmbH.
Exact content by quantitative NMR can be found on the certificate.

Application

Reference standard in the analysis of herbal medicinal products.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
HWI00197-5
HWI00197-3
HWI00197-2
HWI00197-1
HWI00197

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Yen-Chun Chen et al.
Life sciences, 84(25-26), 915-922 (2009-04-28)
To address the possibility that sennoside B inhibition of cell proliferation is mediated via interference with platelet-derived growth factor (PDGF) signaling. Human osteosarcoma MG63 cells were treated with PDGF in the presence or absence of sennoside B. Activation of the
Kento Takayama et al.
Chemical & pharmaceutical bulletin, 59(9), 1106-1109 (2011-09-02)
Daiokanzoto (DKT, combination of rhubarb and glycyrrhiza), a Kampo medicine, is clinically effective for constipation. Sennoside A is well known to induce diarrhea. Sennoside A is a prodrug that is transformed into an active metabolite, rheinanthrone, by intestinal bacteria. In
Acute hemorrhagic colitis following administration of sennosides for colon cleansing.
Burhan Ozdil et al.
The Annals of pharmacotherapy, 44(4), 770-771 (2010-03-25)
Manuk N Manukyan et al.
Surgical laparoscopy, endoscopy & percutaneous techniques, 21(2), 90-93 (2011-04-08)
The aim of this study is to assess 2 different bowel-cleansing agents. The patients were prospectively randomized to 2 arms of sodium phosphate versus Sennoside A+B calcium preparation. Laboratory assessment, body weight, height, and vital signs were obtained at baseline
Katsuhiro Yamasaki et al.
Journal of natural medicines, 64(2), 126-132 (2010-01-22)
The sennoside A (SA) and sennoside B (SB) contents of various samples of crude drugs were determined using solid-phase extraction (SPE) and HPLC. The samples examined were crude drugs (senna leaf, senna pods, and rhubarb), conventional crude drug products, and
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