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S-010

Supelco

Sildenafil solution

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

Empirical Formula (Hill Notation):
C22H30N6O4S
CAS Number:
139755-83-2
Molecular Weight:
474.58
EC Number:
200-659-6
MDL number:
MFCD00867528
UNSPSC Code:
41116107
PubChem Substance ID:
329824411
NACRES:
NA.24

grade

certified reference material

form

liquid

feature

Snap-N-Spike®/Snap-N-Shoot®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

concentration

1.0 mg/mL in methanol

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

pharmaceutical (small molecule)

format

single component solution

storage temp.

−20°C

SMILES string

O=C1NC(C2=C(OCC)C=CC(S(=O)(N3CCN(C)CC3)=O)=C2)=NC4=C1N(C)N=C4CCC

InChI

1S/C22H30N6O4S/c1-5-7-17-19-20(27(4)25-17)22(29)24-21(23-19)16-14-15(8-9-18(16)32-6-2)33(30,31)28-12-10-26(3)11-13-28/h8-9,14H,5-7,10-13H2,1-4H3,(H,23,24,29)

InChI key

BNRNXUUZRGQAQC-UHFFFAOYSA-N

Gene Information

human ... PDE5A(8654)

General description

Sildenafil is a treatment for erectile dysfunction and pulmonary arterial hypertension. Sold under the trade name Viagra®, sildenafil has a history of abuse, including by athletes as a performance enhancing drug. This Certified Spiking Solution® is applicable for use in urine drug testing, sports testing, clinical toxicology or forensic analysis by LC-MS/MS or GC/MS.

Application


  • Effect of topical sildenafil on wound healing and oxidative stress in rats: This study investigates the application of sildenafil in a topical solution form to enhance wound healing and reduce oxidative stress in a rat model, providing insights into its potential therapeutic applications (Tunc and Ercan, 2024).

  • The Physicochemical Compatibility of Sildenafil Injection with Parenteral Medications: Research assesses the compatibility of sildenafil solution when combined with various parenteral medications used in neonatal intensive care, suggesting its safe and effective integration for clinical use (De Silva et al., 2024).

  • Changes in Pulmonary Vascular Resistance and Obstruction Score Following Acute Pulmonary Embolism: This study uses sildenafil in a model of acute pulmonary embolism in pigs to evaluate its effects on pulmonary vascular resistance and obstruction, highlighting its potential in managing this condition (Merit et al., 2024).

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
Viagra is a registered trademark of Pfizer, Inc.

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Target Organs

Eyes,Central nervous system

Storage Class Code

3 - Flammable liquids

WGK

WGK 2

Flash Point(F)

49.5 °F - closed cup

Flash Point(C)

9.7 °C - closed cup

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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[Yesterday, Viagra was a medication].
Jean-Yves Nau
Revue medicale suisse, 9(392), 1396-1397 (2013-07-26)
Deanna Wung
International journal of pharmaceutical compounding, 17(1), 24-27 (2013-05-01)
The drugs tadalafil and sildenafil share the same mechanism. Although more research is necessary to solidify the recommendation of the routine use of tadalafil, human and dog data combined with pharmacokinetic data suggest that dogs may be safely treated for
Hironori Kiso et al.
Biochemical and biophysical research communications, 436(3), 514-518 (2013-06-15)
Transient receptor potential canonical (TRPCs) channels are up-regulated in the development of cardiac hypertrophy. Sildenafil inhibits TRPC6 activation and expression, leading to the prevention of cardiac hypertrophy. However, the effects of sildenafil on the expression of other TRPCs remain unknown.
Souheil M Abdel Nour et al.
Tennessee medicine : journal of the Tennessee Medical Association, 106(3), 34-35 (2013-04-03)
Sildenafil, usually a well-tolerated drug traditionally used for erectile dysfunction (ED), was recently approved for pulmonary arterial hypertension. In the literature, there are few cases of hemoptysis following sildenafil use for ED; however, to our knowledge, we are reporting the
R T Alekperov et al.
Terapevticheskii arkhiv, 85(5), 60-67 (2013-07-04)
To retrospectively analyze the efficacy and safety of sildenafil (Sf) in patients with systemic sclerosis (SS). Sf was used in 16 patients (including 14 women) aged 20-66 years (mean 48.6 +/- 14.6 years; median 51.5 years) with SS of a
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