924202

5-Amino-Thalidomide

≥95%

• Synonym(s): 5-Amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione, C5 Pomalidomide, PROTAC^® research ligand
• Empirical Formula (Hill Notation): C₁₃H₁₁N₃O₄
• CAS Number: 191732-76-0
• Molecular Weight: 273.24
• MDL number: MFCD30188077
• UNSPSC Code: 12352101
• NACRES: NA.22

Properties

• ligand: thalidomide
• Quality Level: 100
• Assay: ≥95%
• form: powder
• SMILES string: O=C1C2=CC=C(N)C=C2C(=O)N1C3C(=O)NC(=O)CC3
• InChI: 1S/C13H11N3O4/c14-6-1-2-7-8(5-6)13(20)16(12(7)19)9-3-4-10(17)15-11(9)18/h1-2,5,9H,3-4,14H2,(H,15,17,18)
• InChI key: IICWMVJMJVXCLY-UHFFFAOYSA-N

Description

Application

5-Amino-Thalidomide is a derivative of the Cereblon (CRBN)-binding ligand thalidomide. 5-Amino-Thalidomide can be used to bind the CRBN E3 ubiquitin ligase in targeted protein degradation research or in the synthesis
of protein degraders with a C5 exit vector. This was previously listed under AMBH2D6FF88F.

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Other Notes

Discovery of novel resorcinol diphenyl ether-based PROTAC-like molecules as dual inhibitors and degraders of PD-L1

Efficient Synthesis of Immunomodulatory Drug Analogues Enables Exploration of Structure-Degradation Relationships

Targeting the C481S Ibrutinib-Resistance Mutation in Bruton′s Tyrosine Kinase Using PROTAC-Mediated Degradation

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Safety Information

• Pictograms: GHS06,GHS08
• Signal Word: Danger
• Hazard Statements: H301,H312,H360FD
• Precautionary Statements: P202 - P264 - P270 - P280 - P301 + P310 - P302 + P352 + P312
• Hazard Classifications: Acute Tox. 3 Oral - Acute Tox. 4 Dermal - Repr. 1A
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable