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705594

Sigma-Aldrich

Cortisol-9,11,12,12-d4

≥98 atom % D, ≥98% (CP)

Synonym(s):

11β,17α,21-Trihydroxypregn-4-ene-3,20-dione-D4, 11β,17α,21-Trihydroxypregn-4-ene-3,20-dione-d4 (9,11,12,12-d4), 17-Hydroxycorticosterone-9,11,12,12-d4, 17-Hydroxycorticosterone-D4, 4-Pregnene-11β,17α,21-triol-3,20-dione-D4, 4-Pregnene-11β,17α,21-triol-3,20-dione-d4 (9,11,12,12-d4), Deuterated cortisol, Deuterated hydrocortisone, Hydrocortisone-9,11,12,12-d4, Kendall′s compound F (9,11,12,12-d4), Reichstein′s substance M (9,11,12,12-d4)

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About This Item

Empirical Formula (Hill Notation):
C21D4H26O5
CAS Number:
73565-87-4
Molecular Weight:
366.48
MDL number:
MFCD10567120
UNSPSC Code:
41116107
PubChem Substance ID:
329762571
NACRES:
NA.24

isotopic purity

≥98 atom % D

Assay

≥98% (CP)

form

powder

technique(s)

mass spectrometry (MS): suitable

mp

211-214 °C

mass shift

M+4

storage temp.

−20°C

SMILES string

[2H]C1([2H])[C@]([2H])(O)[C@@]2([2H])[C@@H](CCC3=CC(=O)CC[C@]23C)[C@@H]4CCC(O)(C(=O)CO)[C@@]14C

InChI

1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1/i10D2,16D,18D

InChI key

JYGXADMDTFJGBT-BJJKTIQHSA-N

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Packaging

This product may be available from bulk stock and can be packaged on demand. For information on pricing, availability and packaging, please contact Stable Isotopes Customer Service.

Pictograms

Health hazard
GHS08

Signal Word

Warning

Hazard Statements

H361

Hazard Classifications

Repr. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Mayako Saito-Abe et al.
Pediatrics international : official journal of the Japan Pediatric Society, 62(7), 785-788 (2020-01-25)
Sampling of salivary cortisol is non-invasive and important for the evaluation of the hypothalamic-pituitary-adrenal axis function and stress levels. However, the reference values for salivary cortisol measured by liquid chromatography-tandem mass spectrometry (LC-MS/MS) in healthy infants are unclear. The aim
Marloes L P Langelaan et al.
Endocrine connections, 7(4), 560-566 (2018-03-14)
Saliva as a diagnostic tool is patient friendly and offers analytical advantages. Hormonal analysis of saliva is not influenced by changes in concentrations of binding globulins as the free concentration of the hormones is measured. Analysis of salivary cortisol is
Is the Correlation between Salivary Cortisol and Serum Cortisol Reliable Enough to Enable Use of Salivary Cortisol Levels in Preterm Infants?
Harish Amin et al.
American journal of perinatology, 34(13), 1302-1305 (2017-05-16)
Therina du Toit et al.
The Journal of steroid biochemistry and molecular biology, 166, 54-67 (2016-06-28)
Adrenal C
Chen Li et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1061-1062, 163-168 (2017-07-25)
Cortisol and cortisone are two important glucocorticoids in human body, their interconversion is controlled by two isotypes of 11β-hydroxy steroid dehydrogenase (11β-HSD1 and 11β-HSD2). The ratio of urinary cortisol to cortisone can be used to assess the activity of 11β-HSDs.
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