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52605

Sigma-Aldrich

Hexamethonium hydroxide solution

~0.1 M in H2O

Synonym(s):

N,N,N,N′,N′,N′-Hexamethylhexamethylenediammonium dihydroxide

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About This Item

Linear Formula:
(CH3)3N(OH)(CH2)6N(OH)(CH3)3
CAS Number:
556-81-0
Molecular Weight:
236.39
MDL number:
MFCD00677130
UNSPSC Code:
12352000
PubChem Substance ID:
57651376
NACRES:
NA.22

concentration

~0.1 M in H2O

impurities

≤0.01% halides (as bromide)

storage temp.

2-8°C

SMILES string

[OH-].[OH-].C[N+](C)(C)CCCCCC[N+](C)(C)C

InChI

1S/C12H30N2.2H2O/c1-13(2,3)11-9-7-8-10-12-14(4,5)6;;/h7-12H2,1-6H3;2*1H2/q+2;;/p-2

InChI key

GYLUMIIRFKDCKI-UHFFFAOYSA-L

Pictograms

Corrosion
GHS05

Signal Word

Danger

Hazard Statements

H314

Precautionary Statements

P280 - P305 + P351 + P338 - P310

Hazard Classifications

Skin Corr. 1B

Storage Class Code

8A - Combustible corrosive hazardous materials

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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P G Dinning et al.
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The rabbit colon consists of four distinct regions. The motility of each region is controlled by myogenic and neurogenic mechanisms. Associating these mechanisms with specific motor patterns throughout all regions of the colon has not previously been achieved. Three sections
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We hypothesized that neuropeptide Y (NPY) exerts vasoconstrictor properties in sciatic nerve blood supply by a Y1 receptor (Y1R) mechanism. Using Doppler ultrasound (40MHz), we measured blood flow velocity through a sciatic nerve supply artery during infusions of NPY and/or
Monalisa W Pereira et al.
Clinical and experimental pharmacology & physiology, 39(10), 869-877 (2012-09-28)
1. The 2 Hz train-of-four ratio (TOF(ratio)) is used to monitor the degree of patient curarization. Using a rat phrenic nerve-hemidiaphragm preparation, we showed that antinicotinic agents, such as hexamethonium, d-tubocurarine and pancuronium, but not cisatracurium, decreased contractions produced by
W J Lavery et al.
Experimental eye research, 111, 88-94 (2013-04-10)
In humans, changing from upright to supine elicits an approximately 10 mmHg increase in cephalic venous pressure caused by the hydrostatic column effect, but episcleral venous pressure (EVP) and intraocular pressure (IOP) rise by only a few mmHg. The dissociation
Anna K Leal et al.
Experimental physiology, 97(12), 1292-1304 (2012-05-15)
Evidence suggests that the muscle mechanoreflex, a circulatory reflex that raises blood pressure and heart rate (HR) upon activation of mechanically sensitive afferent fibres in skeletal muscle, is overactive in hypertension. However, the mechanisms underlying this abnormal reflex function have
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