415057

Magnesium stearate

technical grade

• Synonym(s): Stearic acid magnesium salt
• Linear Formula: [CH₃(CH₂)₁₆CO₂]₂Mg
• CAS Number: 557-04-0
• Molecular Weight: 591.24
• Beilstein: 3919702
• EC Number: 209-150-3
• MDL number: MFCD00036391
• UNSPSC Code: 12352100
• PubChem Substance ID: 24865972
• NACRES: NA.22

Properties

• grade: technical grade
• form: powder
• composition: palmitate salt, 25% ; stearate salt, 65%
• mp: 200 °C (lit.)
• SMILES string: CCCCCCCCCCCCCCCCCC(=O)O[Mg]OC(=O)CCCCCCCCCCCCCCCCC
• InChI: 1S/2C18H36O2.Mg/c2*1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20;/h2*2-17H2,1H3,(H,19,20);/q;;+2/p-2
• InChI key: HQKMJHAJHXVSDF-UHFFFAOYSA-L

Description

General description

Magnesium stearate (Mg-St) is the magnesium salt of stearic acid. Its anhydrate, dihydrate and trihydrate forms have been prepared. The tabletting of the blends of magnesium stearate and lactose granules has been described. The influence of mixing time on hardness, disintegration time and ejection force on the compressed tablets was examined. Mg-St is widely used lubricant in pharmaceutical industry. It also plays a role in delaying the process of dissolution. Its detection in tablets by laser-induced breakdown spectroscopy has been proposed.

Magnesium stearate, the salt of stearic acid, is widely employed as an inactive component in making pharmaceutical tablets.

Application

Magnesium stearate may be used as excipient in the formulations of diclofenac sodium tablets. It may be used for the preparation of tramadol HCl matrix tablets.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: nwg
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves