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T9924

Sigma-Aldrich

Troponin I from human heart

lyophilized powder

Synonym(s):

Tn-I

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About This Item

CAS Number:
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.32

biological source

human heart

Quality Level

form

lyophilized powder

purified by

affinity chromatography

technique(s)

inhibition assay: suitable

solubility

water: 5 vial/mL, clear, colorless

UniProt accession no.

shipped in

dry ice

storage temp.

−20°C

Gene Information

human ... TNNI3(7137)

Application

Troponin I from human heart can be used in studies whether the actin and aldolase can protect rabbit muscle lactate dehydrogenase inhibition by ascorbate or not.

Biochem/physiol Actions

The inhibiting subunit of troponin, responsible for preventing actin-myosin binding and ATPase activity.
Troponin I interacts with tropomyosin for regulating the contraction of striated muscle in a calcium-dependent manner. Additionally, Troponin I can also inhibits actomyosin ATPase and serves as a selective and potent inhibitor of angiogenesis in vivo and in vitro and of tumor metastasis in vivo.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Percy J Russell et al.
Journal of enzyme inhibition and medicinal chemistry, 19(1), 91-98 (2004-06-19)
Muscle-type LDH (LDH-m4) activity is critical for efficient anaerobic glycolysis. The results here show that rabbit LDH-M4 is inhibited by concentrations of ascorbate normally found in tissues. Aldolase and muscle G-actin were found to protect and to reverse inhibitions of
M A Moses et al.
Proceedings of the National Academy of Sciences of the United States of America, 96(6), 2645-2650 (1999-03-17)
Cartilage is an avascular and relatively tumor-resistant tissue. Work from a number of laboratories, including our own, has demonstrated that cartilage is an enriched source of endogenous inhibitors of angiogenesis. In the course of a study designed to identify novel

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