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Key Documents

SML3755

Sigma-Aldrich

ZZL-7

≥98% (HPLC)

Synonym(s):

Ac-AV-OMe, Ac-Ala-Val-OMe, N-(N-Acetyl-L-alanyl)-L-valine, methyl ester

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About This Item

Empirical Formula (Hill Notation):
C11H20N2O4
CAS Number:
Molecular Weight:
244.29
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

Assay

≥98% (HPLC)

form

powder

storage condition

protect from light

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

-10 to -25°C

Biochem/physiol Actions

Serotonin transporter (SERT) and neuronal nitric oxide synthase (nNOS) interaction blocker with antidepressant efficacy in vivo.
ZZL-7 is a dipeptide that disrupts the interaction between serotonin transporter (SERT) and neuronal nitric oxide synthase (nNOS) by targeting the groove between the αB helix and βB folding of the nNOS PDZ domain. ZZL-7 decreases 293T cellular SERT-nNOS complex level (post 2h incubation at 1 μM) and demonstrates antidepressant efficacy in wt, but not nNos-/- mice in vivo (10, 20, and 40 mg/kg via intragastric administration or 10 mg/kg via i.p.) without undesirable side effects to the animals.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

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Design of fast-onset antidepressant by dissociating SERT from nNOS in the DRN
Science, 378(6618), 390-398 (2022)

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