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Key Documents

SML0627

Sigma-Aldrich

ML-SA1

≥95% (HPLC), powder, TRPML channel agonist

Synonym(s):

1-[(1,3-Dihydro-1,3-dioxo-2H-isoindol-2-yl)acetyl]-1,2,3,4-tetrahydro-2,2,4-trimethyl-quinoline, 2-(2-Oxo-2-(2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl)ethyl)isoindoline-1,3-dione, Mucolipin Synthetic Agonist 1

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About This Item

Empirical Formula (Hill Notation):
C22H22N2O3
CAS Number:
332382-54-4
Molecular Weight:
362.42
UNSPSC Code:
12352200
NACRES:
NA.77

product name

ML-SA1, ≥95% (HPLC)

Quality Level

100

Assay

≥95% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 5 mg/mL, clear (warmed)

storage temp.

2-8°C

InChI

1S/C22H22N2O3/c1-14-12-22(2,3)24(18-11-7-6-8-15(14)18)19(25)13-23-20(26)16-9-4-5-10-17(16)21(23)27/h4-11,14H,12-13H2,1-3H3

InChI key

KDDHBJICVBONAX-UHFFFAOYSA-N

Application

ML-SA1 has been used as a transient receptor potential cation channel mucolipin 1 (TRPML1/ML1) agonist.

Biochem/physiol Actions

ML-SA1 is a potent and selective cell permeable agonist of lysosomal mucolipin transient receptor potential channels (TRPML) 1, 2, 3 that significantly increases [Ca2+]cyt in HEK293 cells stably- or transiently-expressing mutant TRPML1 channels ML1-4A.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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