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SAB4200185

Sigma-Aldrich

Anti-GPR39 (C-terminal region) antibody produced in rabbit

enhanced validation

~1.5 mg/mL, affinity isolated antibody

Synonym(s):

Anti-G-protein coupled receptor 39

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~52 kDa

species reactivity

human

enhanced validation

recombinant expression
Learn more about Antibody Enhanced Validation

concentration

~1.5 mg/mL

technique(s)

western blot: 1.5-3.0 μg/mL using cell lysates of HEK-293T over expressing human GPR39

UniProt accession no.

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... GPR39(2863)

General description

GPR39 (G protein-coupled receptor 39) is an orphan member of the ghrelin receptor family expressed in brain and other peripheral tissues.
The full-length biologically active form of GPR39, called GPR39-1a, is found exclusively in peripheral tissues. A truncated spliced variant of GPR39 is expressed in various regions of the brain. GPR39 mRNA is highly expressed in endocrine and metabolic organs such as the pancreas, liver, the gastrointestinal tract and white adipose tissue. GPR39 expression specifically follows the endocrine pancreatic differentiation and is selectively expressed in β-cells of the pancreatic islets.

Application

Anti-GPR39 (C-terminal region) antibody produced in rabbit has been used in immunohistochemistry.
Anti-GPR39 (C-terminal region) antibody produced in rabbit is suitable for western blot at a concentration of 1.5-3.0μg/mL using cell lysates of HEK-293T over expressing human GPR39.

Biochem/physiol Actions

G-protein coupled receptor 39 (GPR39) has been shown to be important regulators of food intake, energy metabolism and glucose homeostasis. GPR39 signals mainly through the Gαq and Gα12/13 leading to inositol phosphate accumulation and activation of downstream pathways such as the nuclear factor of activated T cells (NFAT) transcriptional pathway. GPR39 has been suggested to mediate glutamate metabotropic signaling triggered by synaptically released Zn2+ in the hippocampus. Knockout of GPR39 in mice is found to be associated with impaired insulin secretion, glucose tolerance and altered pancreatic β-cell gene expression and function, suggesting that this receptor could be a novel potential target for the treatment of diabetes.
GPR39 (G protein-coupled receptor 39) exerts ligand-independent signaling activity. It is mainly involved in the regulation of growth hormone secretion. It facilitates the functional activities of the growth hormone-releasing peptides (GHRPs) and non-peptide ligands such as L-692,429 and MK-0677. It has been studied that zinc ion triggers GPR39 activity during food intake and energy metabolism. Study also shows that GPR39 may control the neuronal activity not only by altering transmitter expression and release but also through altering neuronal plasticity.

Physical form

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Novel Zn2+ modulated GPR39 receptor agonists do not drive acute insulin secretion in rodents
Fjellstrom O, et al.
PLoS ONE, 10(12), e0145849-e0145849 (2015)
G protein-coupled receptor 39 deficiency is associated with pancreatic islet dysfunction
Holst B, et al.
Endocrinology, 150(6), 2577-2585 (2009)
GPR39: a Zn 2+-activated G protein-coupled receptor that regulates pancreatic, gastrointestinal and neuronal functions
Popovics P and Stewart AJ
Cellular and Molecular Life Sciences, 68(1), 85-95 (2011)
GPR39 splice variants versus antisense gene LYPD1: expression and regulation in gastrointestinal tract, endocrine pancreas, liver, and white adipose tissue
Egerod K, et al.
Molecular Endocrinology, 21(7), 1685-1698 (2007)
Synaptically released zinc triggers metabotropic signaling via a zinc-sensing receptor in the hippocampus
Besser L, et al.
The Journal of Neuroscience, 29(9), 2890-2901 (2009)

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