P2200
Protein C from human plasma
Activated, lyophilized powder, ≥90% (SDS-PAGE)
Synonym(s):
Activated Protein C
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About This Item
CAS Number:
MDL number:
UNSPSC Code:
12352202
NACRES:
NA.61
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biological source
human plasma
Quality Level
Assay
≥90% (SDS-PAGE)
form
lyophilized powder
mol wt
heavy chain 41 kDa
light chain 21 kDa
technique(s)
inhibition assay: suitable
solubility
H2O: 1 mg/mL
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... PROC(5624)
General description
Protein C from human plasma is encoded by the gene PROC. In human chromosome, the gene is localised on chromosome 2q14.[1] Activated protein C (APC) cleaves protease activated receptor 1 (PAR1) resulting in cytoprotective and anti-inflammatory effects.[2] Clinical trials with APC implicates its use in treating severe early onset preeclampsia in pregnant women and prolongs pregnancy and helps in perinatal outcomes.[3]
Application
Biochem/physiol Actions
In addition, activated protein C has been shown to inhibit TNF-α induced expression of the inflammatory proteins VCAM, ICAM-I, and Ilk-8 in endothelial cells. [5]
Protein C is a plasma, vitamin κ-dependent zymogen of a serine protease that can inhibit blood coagulation by inhibiting thrombin formation, selectively inactivating Factors Va and VIIIa.
Protein C is a plasma, vitamin κ-dependent zymogen of a serine protease that can inhibit blood coagulation by inhibiting thrombin formation, selectively inactivating Factors Va and VIIIa. The Protein C anticoagulant pathway is triggered when thrombin binds to the endothelial cell proteoglycan, thrombomodulin. This complex, which cannot clot blood, is a potent activator of the protein C zymogen. Activation involves the release of a dodecapeptide from the N-terminal domain of the heavy chain. The activated Protein C (APC) then binds to protein S on cell surfaces and inactivates the coagulation factors Va and VIIIa by proteolysis. APC has also been shown to bind to receptors on the endothelium of large blood vessels.
Physical form
Lyophilized powder from 20 mM Tris-HCl, pH 7.4, containing 0.1 M NaCl
Disclaimer
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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K A Hill et al.
The Journal of biological chemistry, 261(32), 14991-14996 (1986-11-15)
The kinetic properties of the activation by monovalent cations of the amidolytic activity of bovine des-1-41 light chain activated protein C have been examined. With the cations Cs+, K+, Li+, and Tl+, a single cation site, or class of sites
David Stacey et al.
Nature communications, 13(1), 1222-1222 (2022-03-11)
Many individual genetic risk loci have been associated with multiple common human diseases. However, the molecular basis of this pleiotropy often remains unclear. We present an integrative approach to reveal the molecular mechanism underlying the PROCR locus, associated with lower
Jinqiao Wang et al.
Dose-response : a publication of International Hormesis Society, 18(2), 1559325820917288-1559325820917288 (2020-05-20)
Although the effect of activated protein C (APC) on neuronal injury and neuroinflammatory responses has been extensively studied, the detailed mechanism underlying APC-protective effect in the blood-brain barrier (BBB) injury during ischemia is still not clear. In this study, the
K A Hill et al.
The Journal of biological chemistry, 262(1), 140-146 (1987-01-05)
A pre-steady state kinetic analysis of the stimulation by monovalent cations of the activity of bovine activated protein C (APC) and a proteolytic fragment of APC, des-1-41-light chain activated protein C (GDAPC), toward the substrate, 4-methylumbelliferyl p-guanidinobenzoate, has been undertaken.
K A Hill et al.
Archives of biochemistry and biophysics, 254(1), 196-202 (1987-04-01)
The binding isotherms of Mn2+ to bovine plasma protein C (PC), des(1-41)-light chain protein C (GDPC), and activated GDPC (GDAPC) have been measured. PC contains 14-16 total Mn2+ binding sites, a value that is reduced to approximately 7-8 in the
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