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Key Documents

P0883

Sigma-Aldrich

Poly(deoxyadenylic-thymidylic) acid sodium salt

double-stranded alternating copolymer

Synonym(s):

Poly(dA-dT) • Poly(dA-dT)

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About This Item

CAS Number:
86828-69-5
MDL number:
MFCD00131964
UNSPSC Code:
41106305
NACRES:
NA.51

Quality Level

200

form

powder

storage temp.

−20°C

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Application

Poly(deoxyadenylic-thymidylic) (Poly(dA-dT) • Poly(dA-dT))acid is a double-stranded alternating copolymer DNA model for conformational studies of DNA structure dynamics and drug interaction.

Other Notes

Double-stranded alternating copolymer.

Unit Definition

One unit will yield an A260 of 1.0 in 1.0 ml 20 mM sodium phosphate/100 mM NaCl, pH 7.0 (1cm light path).

Quantity

One mg is equivalent to ≥12 A260 units.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Marta Airoldi et al.
Journal of biomolecular structure & dynamics, 25(1), 77-84 (2007-08-07)
The thermal denaturation of the synthetic high molecular weight double stranded polynucleotide poly(dA-dT) x poly(dA-dT) has been studied in aqueous buffered solution (Tris 1.0 mM; pH 7.8+/-0.2) in the presence of increasing concentrations of either Ni(2+) (borderline cation) or Cd(2+)
Marta Airoldi et al.
Chirality, 20(9), 951-960 (2008-02-05)
The thermal behavior of the synthetic, high molecular weight, double stranded polynucleotides poly(dA-dT).poly(dA-dT) [polyAT] and poly(dG-dC).poly(dG-dC) [polyGC] solubilized in the aqueous core of the quaternary water-in-oil cationic microemulsion CTAB|n-pentanol|n-hexane|water in the presence of increasing amounts of NiCl(2) at several constant
M Vorlícková et al.
Journal of biomolecular structure & dynamics, 3(1), 67-83 (1985-08-01)
The article reviews data indicating that poly(dA-dT).poly(dA-dT) is able of adopting three distinct double helical structures in solution, of which only the A form conforms to classical notions. The other two structures have dinucleotides as double helical repeats. At low
Jung Hwan Bae et al.
Cells, 8(4) (2019-04-11)
Mitochondrial dysfunction has been implicated in the pathogenesis of insulin resistance and type 2 diabetes. Damaged mitochondria DNA (mtDNA) may have a role in regulating hyperglycemia during type 2 diabetes. Circulating cell-free mitochondria DNA (ccf-mtDNA) was found in serum and
Do Won Lee et al.
Biochemical and biophysical research communications, 493(2), 957-963 (2017-09-25)
Low dose of carbon monoxide (CO) has anti-inflammatory role through various signaling pathways. Cellular metabolism has been implicated in the activation of inflammation in immune cells. However, the mechanisms by which CO-dependent metabolic regulation affect the immune response remain unclear.
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