74817
FITC-CM-Dextran
average mol wt 150,000
Synonym(s):
FITC-CM-Dextran 150, Fluorescein isothiocyanate–Carboxymethyl–Dextran
Sign Into View Organizational & Contract Pricing
All Photos(1)
About This Item
UNSPSC Code:
12352108
NACRES:
NA.32
Recommended Products
biological source
synthetic
Quality Level
conjugate
FITC conjugate
form
powder or crystals
mol wt
average mol wt 150,000
composition
carboxymethyl content, 3-7%
extent of labeling
0.001-0.020 mol FITCmol glucose
fluorescence
λex 493 nm; λem 517 nm±5 nm in 0.1 M Tris pH 8.0
Looking for similar products? Visit Product Comparison Guide
General description
FITC-CM-Dextran, also known as Fluorescein isothiocyanate–Carboxymethyl–Dextran, is an anionic fluorescent probe. The carboxyl group provides the negative charge, which improves the overall permeability of the molecule. It is supplied as a yellow powder that is freely soluble in water and electrolyte solutions. FITC-CM-Dextran is insoluble in most organic samples such as ethanol, methanol, acetone, and chloroform.
FITC-CM-Dextran is manufactured by reacting selected dextran fractions with an activated carboxymethyl derivative in alkali, whereby O-carboxymethyl groups are introduced along the dextran chain.
FITC-CM-Dextran is manufactured by reacting selected dextran fractions with an activated carboxymethyl derivative in alkali, whereby O-carboxymethyl groups are introduced along the dextran chain.
Application
FITC-CM-dextran is used to study drug intake and delivery mechanisms in HeLa cell lines. FITC-CM-Dextran was chosen due to its high water solubility and negative charge.
It is also a suitable molecule to be used in encapsulation studies for polymersomal drug delivery systems or Ps DDS . FITC-CM-Dextran is a biocompatible molecule used as a starting material in several pharmaceutical and diagnostic applications.
It is also a suitable molecule to be used in encapsulation studies for polymersomal drug delivery systems or Ps DDS . FITC-CM-Dextran is a biocompatible molecule used as a starting material in several pharmaceutical and diagnostic applications.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Customers Also Viewed
Marco Romano et al.
Oncoimmunology, 6(10), e1345402-e1345402 (2017-11-11)
Myelofibrosis (MF) is a clonal neoplasia associated with chronic inflammation due to aberrant cytokine production. Mutations in Janus Kinase-2 (JAK2), calreticulin (CALR) and myeloproliferative leukemia protein (MPL) genes have been recently associated to MF and they all activate the JAK/STAT
Chloe Martin et al.
International journal of pharmaceutics, 511(1), 570-578 (2016-07-28)
The need to develop a greater understanding of drug delivery systems has arisen through the development of alternative biological based therapeutics. Drug delivery systems need to adapt and respond to this increasing demand for cellular transportation of highly charged species.
Chloe Martin et al.
International journal of pharmaceutics, 481(1-2), 1-8 (2015-01-17)
The field of therapeutics is evolving to include a greater proportion of higher molecular weight, hydrophilic biological compounds. To cater for this new era in healthcare the concomitant development of appropriate drug delivery systems is essential to aid cellular permeation.
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service