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HKI1MAG-99K

Millipore

MILLIPLEX® Human Kidney Injury Magnetic Bead Panel 1 - Toxicity Multiplex Assay

The analytes available for this multiplex kit are: Calbindin, Collagen IV, Fatty Acid Binding Protein 1 (FABP1), GSTα, IP-10, Kidney Injury Molecule-1 (KIM-1), Renin, TFF-3, TIMP-1.

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About This Item

UNSPSC Code:
12161503
eCl@ss:
32161000
NACRES:
NA.84

Quality Level

200

species reactivity

human

manufacturer/tradename

Milliplex®

assay range

accuracy: 73-117%
sensitivity: 0.010-6.473 ng/mL
(MinDC = 2SD)
standard curve range: 0.005-5 ng/mL
(IP-10)
standard curve range: 0.02-25 ng/mL
(Renin)
standard curve range: 0.05-50 ng/mL
(GSTα)
standard curve range: 0.05-50 ng/mL
(KIM-1)
standard curve range: 0.10-100 ng/mL
(TIMP-1)
standard curve range: 0.20-200 ng/mL
(Calbindin)
standard curve range: 0.34-350 ng/mL
(Collagen IV)
standard curve range: 0.49-500 ng/mL
(TFF-3)
standard curve range: 5.86-6,000 ng/mL
(FABP1)
inter-assay cv: <15%
intra-assay cv: <10%

technique(s)

multiplexing: suitable

detection method

fluorometric (Luminex xMAP)

shipped in

wet ice

General description

Maintenance of physiological balance in the body is attributed in part to normal kidney function. Altered kidney function due to injury, drug toxicity or kidney failure may be life threatening. Toxicity is the leading cause of drug failure, so research is expanding in search of more sensitive, rapid methods to determine organ-specific damage as quickly as possible. Traditionally, blood urea nitrogen (BUN) and serum creatinine tests have been used to determine drug-induced damage to the kidney. These tests only detect kidney damage after it begins and do not allow for the elucidation of where in the kidney the damage has occurred. Specificity and earlier detection of kidney injury is vital, and this area of research is expanding in search of more sensitive, rapid methods for determining the specific area of damage in kidney.

The MILLIPLEX® portfolio provides valuable research assays to investigate multiple biomarkers of kidney injury in human urine samples using the Luminex® xMAP® instrument platform. The analytes available for this multiplex kit are: Calbindin, Collagen IV, Fatty Acid Binding Protein 1 (FABP1), GSTα, IP-10, Kidney Injury Molecule-1 (KIM-1), Renin, TFF-3, TIMP-1.

Panel Type: Toxicity

Specificity

Cross Reactivty
There was no or negligible cross-reactivity between the antibodies for an analyte and any of the other analytes within a panel.

Application

  • Analytes: Calbindin, Collagen IV, FABP1, GSTα, IP-10, KIM-1, Renin, TFF-3, TIMP-1
  • Recommended Sample type: Urine
  • Recommended Sample dilution: 1:2 in kit Assay Buffer Customers need to determine the optimal dilution factor for their samples. Our recommendations are based on urine samples from normal subjects.
  • Assay Run Time: Overnight
  • Research Category: Toxicity

Features and Benefits

Design your multiplex kit by choosing available analytes within this panel.

Other Notes

Sensitivity: Please see kit protocol for individual assay sensitivities.

Legal Information

Luminex is a registered trademark of Luminex Corp
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Sens. 1 - STOT RE 2

Target Organs

Respiratory Tract

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Hui Huang et al.
Journal of translational medicine, 20(1), 102-102 (2022-02-25)
Acute kidney injury (AKI) is associated with high morbidity and mortality. Multiple urinary biomarkers have been identified to be associated with the prediction of AKI and outcomes. However, the accuracy of these urinary biomarkers for AKI and associated outcomes has
Irene Capelli et al.
In vivo (Athens, Greece), 34(3), 1333-1339 (2020-05-02)
Acute kidney injury is an important cause of mortality in very-low-birth-weight (VLBW) preterm infants. As in the general population, the detection of renal damage cannot rely on the measurement of serum creatinine, since it has been demonstrated to be a
Leonardo Trasande et al.
Environmental pollution (Barking, Essex : 1987), 256, 113334-113334 (2019-11-05)
The goal of this study was to assess biomarkers of exposure to glyphosate and assess potential associations with renal function in children. Glyphosate is used ubiquitously in agriculture worldwide. While previous studies have indicated that glyphosate may have nephrotoxic effects

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