T-074

3,3′,5-Triiodo-L-thyronine (T₃) solution

100 μg/mL in methanol with 0.1N NH₃, ampule of 1 mL, certified reference material, Cerilliant^®

• Synonym(s): 3,3′,5-Triiodo-L-thyronine, O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine, Liothyronine, T₃
• Empirical Formula (Hill Notation): C₁₅H₁₂I₃NO₄
• CAS Number: 6893-02-3
• Molecular Weight: 650.97
• Beilstein: 2710227
• MDL number: MFCD00002593
• UNSPSC Code: 41116107
• PubChem Substance ID: 329826618
• NACRES: NA.24

Properties

• grade: certified reference material
• form: liquid
• feature: Snap-N-Spike^®/Snap-N-Shoot^®
• packaging: ampule of 1 mL
• manufacturer/tradename: Cerilliant^®
• concentration: 100 μg/mL in methanol with 0.1N NH₃
• technique(s): gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• mp: 234-238 °C (lit.)
• application(s): clinical testing; clinical testing
• format: single component solution
• storage temp.: −20°C
• SMILES string: N[C@@H](Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1)C(O)=O
• InChI: 1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1
• InChI key: AUYYCJSJGJYCDS-LBPRGKRZSA-N
• Gene Information: human ... THRA(7067) , THRB(7068)

Description

General description

This Certified Spiking Solution^® is suitable for use as a starting material in the preparation of linearity standards, calibrators, and controls for thyroid hormone testing methods by LC-MS/MS.

3,3′,5-Triiodo-L-thyronine (T₃) is a thyroid hormone and active form of L-thyroxine (T₄), formed by deiodinase type I or II. It supports various physiological functions, such as oxygen consumption, carbohydrate metabolism, protein synthesis, and neural development. Free and total T₃ serum levels are measured by LC-MS/MS for the determination of hyperthyroidism caused by excess T₃.

Application

The Certified Reference Material (CRM) in solution can also be used as follows:

• Multi-residue determination of seven thyroid hormones in placenta samples by isotope dilution liquid chromatography-quadrupole time-of-flight mass spectrometry (LC-Q-TOF-MS)
• Parts-per-trillion analysis of five thyroid hormones in zebrafish larvae by their solid phase extraction (SPE) and ultra-high performance liquid chromatography-electrospray ionization- tandem mass spectrometric (UPLC-ESI/MS/MS) analysis
• Simultaneous analysis of six free thyroid hormones in bovine serum samples by ultrafiltration and high-performance liquid chromatography (HPLC)-tandem mass spectrometry (MS/MS)
• Determination of six thyroid hormones in mouse tissue samples by isotope dilution nano-ultraperformance liquid chromatography–quadrupole time-of-flight mass spectrometry (Q-TOF-MS)
• Identification and quantification of triiodothyronine and thyroxine in rat serum samples using liquid chromatography-tandem mass spectrometry (LC-MS/MS)

Features and Benefits

• Fully characterized under ISO/IEC 17025 and ISO 17034 accreditation
• Accompanied with a comprehensive Certificate of Analysis (CoA) with data on stability, homogeneity, accuracy of concentration, uncertainty, and traceability
• Rigorously tested through real-time stability studies to ensure accuracy and shelf life
• Gravimetrically prepared using qualified precision balances to ensure minimal uncertainty
• Flame sealed under argon into ampoules for long-term shelf life
• Offered in a convenient, DEA-exempt format to improve laboratory efficiency

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

CERTIFIED SPIKING SOLUTIONS is a registered trademark of Merck KGaA, Darmstadt, Germany

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Pictograms: GHS02,GHS06,GHS08
• Signal Word: Danger
• Hazard Statements: H225,H301 + H311 + H331,H370,H412
• Precautionary Statements: P210 - P273 - P280 - P301 + P310 - P303 + P361 + P353 - P304 + P340 + P311
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Chronic 3 - Flam. Liq. 2 - STOT SE 1
• Target Organs: Eyes,Central nervous system
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 2
• Flash Point(F): 49.5 °F - closed cup
• Flash Point(C): 9.7 °C - closed cup