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Key Documents

L040082

Sigma-Aldrich

Cap A

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About This Item

UNSPSC Code:
12352200
NACRES:
NA.21

type

for DNA synthesis

Quality Level

product line

Proligo Reagents

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Preparation Note

Acetic Anhydride / Tetrahydrofurane 9.1/90.9 (v/v)

Other Notes

Cap A solution, containing acetic anhydride and tetrahydrofuran (THF), is used after the phosphoramidite reaction/coupling step. This solution aborts chains bearing unreacted 5′hydroxyl groups due to failure of reaction with activated phosphoramidite (typically, 1 to 2% of growing oligonucleotide chains in each synthesis cycle). These unreacted 5′hydroxyl groups are capped with an acetyl group and thus rendered unreactive for subsequent synthesis steps.

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Dam. 1 - Flam. Liq. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Supplementary Hazards

Storage Class Code

3 - Flammable liquids

WGK

WGK 1

Flash Point(F)

6.1 °F

Flash Point(C)

-14.4 °C


Certificates of Analysis (COA)

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