900656
Methoxy poly(ethylene glycol)-b-poly(L-lactide)
5k-10k
Synonym(s):
mPEG-b-PLA, mPEG-PLA, mPEG-PLLA
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About This Item
Linear Formula:
HO[CH(CH3)COO]m[CH2CH2O]nCH3
UNSPSC Code:
12162002
NACRES:
NA.23
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Application
Biocompatible, amphiphilic block copolymer composed of a hydrophilic PEG block and a hydrophobic poly(L-lactide) (PLLA) block. These materials have been used in control release and nanoparticle formulation for drug encapsulation and delivery applications. Well-defined materials with varying properties can be prepared by controlling the relative length of each polymer block. Hydroxyl termination allows for facile further chemical modification of these materials.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
>230.7 °F
Flash Point(C)
> 110.4 °C
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Injectable biodegradable polymeric system for preserving the active form and delayed-release of camptothecin anticancer drugs.
Mert O, et al.
Royal Society of Chemistry Advances, 2(1), 176-185 (2012)
Zhigang Xie et al.
Journal of biomedical materials research. Part A, 88(1), 238-245 (2008-02-21)
Docetaxel (DX) is one of the most effective antineoplastic drugs. Its current clinical administration is limited because of its hydrophobicity and serious side effects. A polymer/DX conjugate is designed and successfully prepared to solve these problems. It is monomethoxy-poly(ethylene glycol)-block-poly(L-lactide)/DX
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