155225
2-Piperidinemethanol
97%
Synonym(s):
2-(Hydroxymethyl)piperidine
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About This Item
Recommended Products
Quality Level
Assay
97%
form
solid
mp
68-70 °C (lit.)
SMILES string
OCC1CCCCN1
InChI
1S/C6H13NO/c8-5-6-3-1-2-4-7-6/h6-8H,1-5H2
InChI key
PRAYXGYYVXRDDW-UHFFFAOYSA-N
Application
2-Piperidinemethanol was used in the synthesis of 3-phenyloctahydropyrido[2,1-c][1,4]oxazine hydrochloride and the 10R and 10S diastereomers.
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Dam. 1 - Skin Corr. 1B
Storage Class Code
8A - Combustible corrosive hazardous materials
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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3-Phenyloctahydropyrido[2,1-c][1,4]oxazine hydrochloride and the 10R and 10S diastereomers have been synthesized from (+/-)-, (+)-, and (-)-2-piperidinemethanol. Treatment of 2-piperidinemethanol with alpha-bromoacetophenone gave 3-hydroxy-3-phenyloctahydropyrido[2,1-c][1,4]oxazine which was readily converted to the 3-phenyl derivative by catalytic hydrogenolysis. These compounds were shown to possess
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