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Merck

1173508

USP

Desoximetasone

United States Pharmacopeia (USP) Reference Standard

Sinónimos:

9-Fluoro-11β,21-dihydroxy-16α-methylpregna-1,4-diene-3,20-dione

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About This Item

Fórmula empírica (notación de Hill):
C22H29FO4
Número de CAS:
Peso molecular:
376.46
MDL number:
UNSPSC Code:
41116107
NACRES:
NA.24

biological source

synthetic

agency

USP

vapor pressure

<0.0000001 kPa ( 25 °C)

API family

desoximetasone

form

powder

packaging

pkg of 200 mg

manufacturer/tradename

USP

storage condition

protect from light

color

white

solubility

acetone: freely soluble
alcohol: freely soluble
benzene: slightly soluble
chloroform: freely soluble
ether: slightly soluble
water: insoluble

application(s)

pharmaceutical (small molecule)

SMILES string

[H][C@@]12C[C@@H](C)[C@H](C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]3(F)[C@@]2([H])CCC4=CC(=O)C=C[C@]34C

InChI

1S/C22H29FO4/c1-12-8-16-15-5-4-13-9-14(25)6-7-21(13,3)22(15,23)18(27)10-20(16,2)19(12)17(26)11-24/h6-7,9,12,15-16,18-19,24,27H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,18+,19-,20+,21+,22+/m1/s1

InChI key

VWVSBHGCDBMOOT-IIEHVVJPSA-N

Gene Information

human ... NR3C1(2908)

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General description

Desoximetasone is a topical corticosteroid known to modify the functions of leukocytes that are mainly responsible for skin infections, inflammation and allergies.

Application

Desoximetasone USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Desoximetasone Cream
  • Desoximetasone Gel
  • Desoximetasone Ointment
  • Dexamethasone

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

related product

Referencia del producto
Descripción
Precios

pictograms

Health hazardExclamation mark

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Repr. 2 - Skin Sens. 1

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificados de análisis (COA)

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Visite la Librería de documentos

Development and Validation of RP-HPLC Method for Desoximetasone in Bulk and Cream Formulation
Gorle A, et al.
Journal of Drug Delivery and Therapeutics, 9(3), 154-159 (2019)
Topical corticosteroids: mechanisms of action.
Kragballe, K
Acta Dermato-Venereologica. Supplementum, 151(3), 7-7 (1989)
S Vladimirov et al.
Journal of pharmaceutical and biomedical analysis, 14(8-10), 947-950 (1996-06-01)
The proposed method is based on coloured hydrazone formation with 1,4-dihydrazinophthalazine as a reagent. Heating at 85 degrees C for 2 h was found necessary to ensure optimal hydrazone formation in the presence of hydrochloric acid. The yellow hydrazone product
Desoximetasone USP Monograph
USP43-NF38: United States Pharmacopeia and National Formulary
United States Pharmacopeia, 44(2), 1272-1272 (2020)

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