11023AST
Astec® CHIROBIOTIC® V Chiral (5 μm) HPLC Columns
L × I.D. 15 cm × 4.6 mm, HPLC Column
Sinónimos:
Vancomycin Chiral Column
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About This Item
Código UNSPSC:
41115700
eCl@ss:
32110501
NACRES:
SB.52
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Nombre del producto
Astec® Chirobiotic® V Chiral HPLC Column, 5 μm particle size, L × I.D. 15 cm × 4.6 mm
Materiales
stainless steel column
Agency
suitable for USP L88
descripción
HPLC Column
Línea del producto
Astec®
envase
pkg of 1 ea
fabricante / nombre comercial
Astec®
Parámetros
0-45 °C temperature
80-110 bar pressure (1200-1500 psi)
técnicas
HPLC: suitable
LC/MS: suitable
L × D.I.
15 cm × 4.6 mm
Matriz
High-purity silica gel particle platform
fully porous particle
grupo activo de la matriz
vancomycin phase
tamaño de partícula
5 μm
tamaño de poro
100 Å
intervalo de pH
3.5-7.0
técnica de separación
chiral
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Descripción general
Neutral molecules, amides, acids, esters and amines show considerable enantioselectivity on these vancomycin-based CSPs. A wide variety of secondary and tertiary amines have been separated on the CHIROBIOTIC® V in the polar ionic mode. The CHIROBIOTIC® V has demonstrated many of the separation characteristics of protein-based stationary phases, but with exceptional stability and much higher sample capacity. Some chiral analytes have been resolved that have not been reported separated on any other chiral stationary phase. CHIROBIOTIC® V and V2 differ in their bonding chemistry the pore size of the support particle, giving them different selectivity and preparative capacity.
- Bonded phase: Vancomycin
- Operating pH range: 3.5 - 7.0
- Particle diameter: 5, 10 or 16 μm
- Pore size: 100 Å (CHIROBIOTIC® V) or 200 Å (CHIROBIOTIC® V2)
Aplicación
- Development and validation of an UFLC-MS/MS method for enantioselectivity determination of d,l-thero-methylphenidate, d,l-thero-ethylphenidate and d,l-thero-ritalinic acid in rat plasma and its application to pharmacokinetic study.: This study highlights the application of UFLC-MS/MS combined with Astec® CHIROBIOTIC® V Chiral HPLC Column for the enantioselective analysis of various therapeutic agents in rat plasma, providing a crucial methodological advancement for pharmacokinetic research ( Zhang et al., 2016).
Información legal
Astec is a registered trademark of Merck KGaA, Darmstadt, Germany
CHIROBIOTIC is a registered trademark of Sigma-Aldrich Co. LLC
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Chiral stability-indicating HPLC method for analysis of arotinolol in pharmaceutical formulation and human plasma
Sultan, Maha A., et al.
Arabian Journal of Chemistry, 3 (3), 147-153 (2010)
Hisham Hashem et al.
Journal of chromatography. A, 1218(38), 6727-6731 (2011-08-23)
In this study, a method for enantioseparation of terbutaline and salbutamol was established using Chirobiotic V column as a stationary phase. Polar ionic mode applying mobile phase containing ammonium nitrate in 100% ethanol, pH 5.1 was found to give the
Ana R Ribeiro et al.
Chemosphere, 95, 589-596 (2013-11-05)
Microbial degradation is the most important process to remove organic pollutants in Waste Water Treatment Plants. Regarding chiral compounds this process is normally enantioselective and needs the suitable analytical methodology to follow the removal of both enantiomers in an accurate
Enantiomeric separation of mirtazapine and its metabolite in rat plasma by reverse polar ionic liquid chromatography using fluorescence and polarimetric detectors connected in series
Rao, R. Nageswara, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 879 (21), 1911-1916 (2011)
Sherri L MacLeod et al.
Journal of chromatography. A, 1170(1-2), 23-33 (2007-10-05)
A reversed-phase enantioselective liquid chromatography-tandem mass spectrometry (HPLC-MS-MS) method was developed to measure enantiomer fractions (EF) and concentrations of pharmaceuticals in wastewater. Enantiomer resolution of six beta-blockers (atenolol, metoprolol, nadolol, pindolol, propranolol, and sotalol) along with two selective serotonin re-uptake
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