WH0000675M1

Monoclonal Anti-BRCA2 antibody produced in mouse

clone 3D12, purified immunoglobulin, buffered aqueous solution

• Sinónimos: Anti-FACD, Anti-FAD, Anti-FAD1, Anti-FANCB, Anti-FANCD, Anti-FANCD1, Anti-breast cancer 2, early onset
• Número MDL: MFCD01321778
• Código UNSPSC: 12352203
• NACRES: NA.41

Propiedades

• origen biológico: mouse
• Nivel de calidad: 100
• conjugado: unconjugated
• forma del anticuerpo: purified immunoglobulin
• tipo de anticuerpo: primary antibodies
• clon: 3D12, monoclonal
• Formulario: buffered aqueous solution
• reactividad de especies: human
• técnicas: indirect ELISA: suitable; western blot: 1-5 μg/mL
• isotipo: IgG3κ
• Nº de acceso GenBank: NM_000059
• Nº de acceso UniProt: P51587
• Condiciones de envío: dry ice
• temp. de almacenamiento: −20°C
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... BRCA2(675)

Descripción

Descripción general

Breast cancer type 2 susceptibility protein (BRCA2), DNA repair associated gene is located on human chromosome 13q13.1. BRCA2 and BRCA1 colocalize in subnuclear foci in somatic cells and on the axial elements of developing synaptonemal complexes.

Inmunógeno

BRCA2 (NP_000050, 3319 a.a. ~ 3418 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
SPQMTPFKKFNEISLLESNSIADEELALINTQALLSGSTGEKQFISVSESTRTAPTSSEDYLRLKRRCTTSLIKEQESSQASTEECEKNKQDTITTKKYI

Acciones bioquímicas o fisiológicas

Breast cancer type 2 susceptibility protein (BRCA2), DNA repair associated protein encodes a protein that promotes homologous recombination, which is essential for normal development. Mutations causes tumor formation and cell lethality. Bi-allelic mutations of BRCA2 is associated with Fanconi anemia (FA). BRCA2 alterations can be used as a prognostic marker for pancreatic cancer.

Características y beneficios

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Forma física

Solution in phosphate buffered saline, pH 7.4

Información legal

GenBank is a registered trademark of United States Department of Health and Human Services

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)