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U3633

Sigma-Aldrich

U 18666A

powder

Sinónimos:

(3β)-3-[2-(Diethylamino)ethoxy]androst-5-en-17-one hydrochloride

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About This Item

Fórmula empírica (notación de Hill):
C25H41NO2·HCl
Número de CAS:
3039-71-2
Peso molecular:
424.06
Número MDL:
MFCD00210908
Código UNSPSC:
12352200
ID de la sustancia en PubChem:
24724638
NACRES:
NA.77

Ensayo

≥98% (HPLC)

Formulario

powder

color

white to off-white

mp

195-196.5 °C (lit.)

solubilidad

H2O: 10 mg/mL≥

temp. de almacenamiento

2-8°C

cadena SMILES

Cl[H].[H][C@@]12CC=C3C[C@H](CC[C@]3(C)[C@@]1([H])CC[C@]4(C)C(=O)CC[C@@]24[H])OCCN(CC)CC

InChI

1S/C25H41NO2.ClH/c1-5-26(6-2)15-16-28-19-11-13-24(3)18(17-19)7-8-20-21-9-10-23(27)25(21,4)14-12-22(20)24;/h7,19-22H,5-6,8-17H2,1-4H3;1H/t19-,20-,21-,22-,24-,25-;/m0./s1

Clave InChI

GZFYZYBWLCYBMI-MYZJJQSMSA-N

Descripción general

U18666A, a cationic amphiphile/sterol, has a diethylaminoethyl chain linked to the 3-hydroxyl. It is an androstenolone derivative.

Aplicación

U 18666A has been used in fibroblast controls to study the mechanism of increase in autophagy in Niemann-Pick Disease Type C (NPC) cells.
U 18666A has been used:
  • as a competitive inhibitor of the Niemann-Pick disease, type C (NPC2) binding partner Niemann-Pick C1 (NPC1) to treat symbiotic and aposymbiotic adult Aiptasia to study the effect of global sterol transport inhibition
  • in treating seminiferous tubules to study its effects on the localization pattern of VPS35-positive vesicles
  • to study the U18666A treatment effects on early endosomes and late endosomes/multivesicular bodies (MVBs)
  • as an NPC1 inhibitor to test its in vivo efficacy and study its effects on filovirus entry and infection

Acciones bioquímicas o fisiológicas

Inhibitor of cholesterol synthesis (inhibits desmosterol Δ24-reductase). Weak inhibitor of hedgehog (hh) signaling.
U18666A, a Niemann-Pick phenotype inducer, can inhibit the lysosomal cholesterol export and Ebola infection.

Nota de preparación

U 18666A is soluble in water at 10 mg/ml.

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

Eyeshields, Gloves, type N95 (US)

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Certificados de análisis (COA)

Lot/Batch Number
0000419530
0000419530
0000409931
0000409931
0000163876

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Elena Piccoli et al.
Biochemical pharmacology, 82(9), 1234-1249 (2011-09-01)
Patients treated with amiodarone accumulate lysobisphosphatidic acid (LBPA), also known as bis(monoacylglycero)phosphate, in airway secretions and develop in different tissues vacuoles and inclusion bodies thought to originate from endosomes. To clarify the origin of these changes, we studied in vitro
Anton I Rosenbaum et al.
Proceedings of the National Academy of Sciences of the United States of America, 107(12), 5477-5482 (2010-03-10)
Niemann-Pick type C disease (NPC) is a lysosomal storage disorder causing accumulation of unesterified cholesterol in lysosomal storage organelles. Recent studies have shown that hydroxypropyl-beta-cyclodextrin injections in npc1(-/-) mice are partially effective in treating this disease. Using cultured fibroblasts, we
Hanna Appelqvist et al.
The American journal of pathology, 178(2), 629-639 (2011-02-02)
In the past decade, lysosomal membrane permeabilization (LMP) has emerged as a significant component of cell death signaling. The mechanisms by which lysosomal stability is regulated are not yet fully understood, but changes in the lysosomal membrane lipid composition have
Jing Xu et al.
Proceedings of the National Academy of Sciences of the United States of America, 107(10), 4764-4769 (2010-02-24)
Mammalian target of rapamycin (mTOR) constitutes a nodal point of a signaling network that regulates cell growth and proliferation in response to various environmental cues ranging from growth factor stimulation to nutrients to stress. Whether mTOR is also affected by
Marie-Claude Battista et al.
The Prostate, 70(9), 921-933 (2010-02-19)
Seladin-1 belongs to a subgroup of androgen-dependent genes associated with anti-proliferative, pro-differentiation, and pro-apoptotic functions and plays a protective role against oncogenic stress. The present study aims to investigate the localization and expression of Seladin-1 protein in normal and tumoral
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