T6031

DL-Thiorphan

≥98% (TLC)

• Sinónimos: (±)-N-(3-Mercapto-2-benzylpropionyl)glycine, DL-3-Mercapto-2-benzylpropanoylglycine
• Fórmula empírica (notación de Hill): C₁₂H₁₅NO₃S
• Número de CAS: 76721-89-6
• Peso molecular: 253.32
• Beilstein: 4872101
• Número MDL: MFCD00058435
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 24278747
• NACRES: NA.77

Propiedades

• Nivel de calidad: 200
• Ensayo: ≥98% (TLC)
• Formulario: powder
• mp: 138 °C
• solubilidad: ethanol: soluble 49.00-51.00 mg/mL, clear, colorless
• cadena SMILES: OC(=O)CNC(=O)C(CS)Cc1ccccc1
• InChI: 1S/C12H15NO3S/c14-11(15)7-13-12(16)10(8-17)6-9-4-2-1-3-5-9/h1-5,10,17H,6-8H2,(H,13,16)(H,14,15)
• Clave InChI: LJJKNPQAGWVLDQ-UHFFFAOYSA-N
• Información sobre el gen: human ... ACE(1636) , ECE1(1889) ; rat ... Ace(24310) , Mme(24590)

Descripción

Descripción general

Thiorphan, also called DL-mercapto-2-benzylpropanoyl-glycine is a specific and potent inhibitor of enkephalinase in nanomolar concentrations. It is an inhibitor of neutral endopeptidase. It interacts with cluster of differentiation 10 (CD10) in bone marrow cells and may modulate hematopoiesis. Thiorphan is a safe drugprescribed for diarrhea. It prevents cortical damage in newborn mice and is a potent agent for treating cerebral palsy.(CP)

Aplicación

DL-Thiorphan has been used to evaluate the activity of NEP-dependent neutral endopeptidase. DL-Thiorphan has also been used for determining NEP enzymatic activity using fluorimetric assays.

Acciones bioquímicas o fisiológicas

Enkephalinase inhibitor.

Características y beneficios

This compound is featured on the Neuropeptidases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Nota de preparación

DL-Thiorphan is soluble in ethanol at 49.00 - 51.00 mg/ml and yields a clear, colorless solution.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Gloves, type N95 (US)