SRP8024
TRAIL, Soluble human
recombinant, expressed in E. coli, His tagged, >98% (SDS-PAGE)
Sinónimos:
Apo-2L, CD253, CD339, TRAIL
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About This Item
Código UNSPSC:
12352200
NACRES:
NA.77
Productos recomendados
origen biológico
human
recombinante
expressed in E. coli
etiqueta
His tagged
Ensayo
>98% (SDS-PAGE)
Formulario
liquid
mol peso
~26 kDa
envase
pkg of 20 μg
concentración
≥0.2 mg/mL
técnicas
activity assay: suitable
cell culture | mammalian: suitable
transfection: suitable
impurezas
<0.01 EU/μg endotoxin, tested
color
clear
Nº de acceso UniProt
Condiciones de envío
dry ice
temp. de almacenamiento
−70°C
Información sobre el gen
human ... TNFSF10(8743)
Descripción general
TNF-related apoptosis-inducing ligand (TRAIL; Apo2L; CD253; TNFSF10) is a type II transmembrane protein of about 34kDa. Like most members of the tumor necrosis factor (TNF) superfamily of cytokines, TRAIL can be cleaved at the cell surface by metalloproteases to form a soluble molecule. The gene encoding TRAIL is localized on human chromosome 3q26.31.
Aplicación
TRAIL, soluble human has been used in cell culture, chemical transfection and in caspase-3/7 activity assay.
Acciones bioquímicas o fisiológicas
Trimerized TNF-related apoptosis-inducing ligand (TRAIL) triggers apoptosis upon ligation of cell surface TRAIL-receptor 1 (R1) and/or TRAIL-R2 by inducing the formation of the so-called multiprotein death-inducing signaling complex (DISC). Active TRAIL forms trimers and specifically binds to five distinct receptors: TRAIL-receptors 1,-2,-3,-4 {TRAIL-R1 (DR4; Apo2; CD261; TNFRSF10A), TRAIL-R2 (DR5; KILLER; TRICK2A; TRICK2B; CD262; TNFRSF10B), TRAIL-R3 (DcR1; LIT; TRID; CD263; TNFRSF10C), TRAIL-R4 (DcR2; TRUNDD; CD264; TNFRSF10D)} and osteoprotegerin (OPG; OCIF; TNFRSF11B).
Forma física
Solution in 20 mM HEPES, pH 7.9, 120 mM NaCl, 0.01% Tween 20, 1% sucrose, 1 mM DTT.
Otras notas
The extracellular domain of human TRAIL (aa 95-281) is fused at the N-terminus to a His-tag and a linker peptide. The active multimeric conformation is stabilized by an inserted mutation allowing an additional CC-bridge.
Código de clase de almacenamiento
12 - Non Combustible Liquids
Clase de riesgo para el agua (WGK)
WGK 1
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
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Association of TRAIL and Its Receptors with Large-Artery Atherosclerotic Stroke.
Pan X
PLoS ONE, 10(9), e0136414-e0136414 (2015)
Genome-Scale MicroRNA and Small Interfering RNA Screens Identify Small RNA Modulators of TRAIL-Induced Apoptosis Pathway
Dmitriy Ovcharenko
Cancer Research (2007)
Association between endometriosis and polymorphisms in tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), TRAIL receptor and osteoprotegerin genes and their serum levels.
Kim H
Archives of Gynecology and Obstetrics, 286(1), 147-153 (2012)
Intracranial AAV-sTRAIL combined with lanatoside C prolongs survival in an orthotopic xenograft mouse model of invasive glioblastoma.
Crommentuijn MH
Molecular Oncology, 10(4), 625-634 (2016)
Tumor Necrosis Factor-a Blocks Apoptosis in Melanoma Cells when BRAF Signaling Is Inhibited
Vanessa C Gray-Schopfer
Cancer Research (2007)
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