SRP5255
HSP70, GST tagged human
recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
Sinónimos:
HSP70-1, HSP72, HSPA1, HSPA1A, HSPA1B. DAQB-147D11.1
Iniciar sesiónpara Ver la Fijación de precios por contrato y de la organización
About This Item
Productos recomendados
origen biológico
human
recombinante
expressed in E. coli
Ensayo
≥70% (SDS-PAGE)
Formulario
buffered aqueous glycerol solution
mol peso
~96 kDa
Nº de acceso NCBI
aplicaciones
cell analysis
Condiciones de envío
dry ice
temp. de almacenamiento
−70°C
Información sobre el gen
human ... HSPA1A(3303)
Descripción general
HSP70 is a member of the heat shock protein family and is synthesized by cells of many organisms in response to stress. HSP70 is found mostly but not exclusively in the nucleus of unstressed cells. For several hours after a short heat shock, however, it is strongly concentrated in nucleoli. Nucleoli are transiently damaged by such a heat shock: their morphology changes and assembly and export of ribosomes is blocked for several hours. HSP70 helps to stabilize the morphological changes of the nucleoli.
HSP70 (heat shock 70kDa)/Hsp70A1A (heat shock 70kDa protein 1A) is also termed as HSP72. It belongs to the molecular chaperones family. This gene is located on human chromosome 6p21.
HSP70 (heat shock 70kDa)/Hsp70A1A (heat shock 70kDa protein 1A) is also termed as HSP72. It belongs to the molecular chaperones family. This gene is located on human chromosome 6p21.
Acciones bioquímicas o fisiológicas
HSP70 (heat shock 70kDa)/Hsp70A1A (heat shock 70kDa protein 1A) participates in several cellular processes, such as thermotolerance, clearance of protein aggregate, survival and proliferation. Mutation in Hsp70 gene locus is linked with systemic lupus erythematosus. Overexpression of this protein is observed in valproic acid (VPA)-resistant cell lines.
Forma física
Supplied in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.
Nota de preparación
After opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles.
Código de clase de almacenamiento
10 - Combustible liquids
Clase de riesgo para el agua (WGK)
WGK 1
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Elija entre una de las versiones más recientes:
Certificados de análisis (COA)
Lot/Batch Number
¿No ve la versión correcta?
Si necesita una versión concreta, puede buscar un certificado específico por el número de lote.
¿Ya tiene este producto?
Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.
The impact of heat shock protein 70 gene variations on clinical presentation and outcome in schizophrenic inpatients
Pae C U, et al.
Neuropsychobiology, 59(3), 135-141 (2009)
Engagement of Components of DNA-Break Repair Complex and NF kappaB in Hsp70A1A Transcription Upregulation by Heat Shock
Hazra J, et al.
Testing, 12(1), e0168165-e0168165 (2017)
Polymorphisms in the Hsp70 gene locus are genetically associated with systemic lupus erythematosus
Furnrohr BG, et al.
Annals of the Rheumatic Diseases, annrheumdis122630-annrheumdis122630 (2010)
HSP72 functionally inhibits the anti-neoplastic effects of HDAC inhibitors
Fujii K, et al.
Journal of Dermatological Science, 90(1), 82-89 (2018)
Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.
Póngase en contacto con el Servicio técnico