SRP3147
Relaxin-2 Peptide
≥98% (HPLC), human recombinant, expressed in E. coli, suitable for cell culture
Sinónimos:
H2 relaxin, RLN2
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About This Item
Código UNSPSC:
12352202
NACRES:
NA.32
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Nombre del producto
Relaxin-2 human, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture
origen biológico
human
recombinante
expressed in E. coli
Ensayo
≥98% (HPLC)
≥98% (SDS-PAGE)
Formulario
lyophilized
mol peso
6.0 kDa
envase
pkg of 25 μg
técnicas
cell culture | mammalian: suitable
impurezas
<0.1 EU/μg endotoxin, tested
color
white
Nº de acceso UniProt
Condiciones de envío
wet ice
temp. de almacenamiento
−20°C
Información sobre el gen
human ... RLN2(6019)
Categorías relacionadas
Descripción general
Relaxin-2 is a peptide hormone structurally related to insulin. The gene is mapped to human chromosome 9p24. It is expressed in the placenta, decidua, prostate, corpus luteum, endometrium, mammary glands, heart, and brain. It is also expressed in the ovary during pregnancy. Recombinant relaxin-2 is a nonglycosylated 6kDa disulfide linked heterodimeric protein consisting of a 24 amino acid A-chain and a 29 amino acid B-chain.
Aplicación
It has also been used to study its effect on human endometrial carcinoma cell lines.
Relaxin-2 human has been used to study the effect of testosterone on the expression of relaxin receptor in the knee joint.
Acciones bioquímicas o fisiológicas
Of the three known relaxin genes, Relaxin-2 (RLN2) is the only relaxin known to circulate in the blood. Relaxin-2 binds specifically to the LGR7 (leucine-rich repeat-containing G-protein coupled receptor 7) and LGR8 receptors, previously identified as an "orphan" G protein coupled receptors. Signaling by Relaxin-2 through its target receptors enhances the growth of pubic ligaments and ripening of the cervix during birth. Relaxin-2 also participates in cancer progression. In prostate cancer, it is responsible for tumor growth and vascularisation. Relaxin-2 is also linked with anti-fibrotic and cardioprotective effects.
Secuencia
A-Chain: QLYSALANKC CHVGCTKRSL ARFC B-Chain: DSWMEEVIKL CGRELVRAQI AICGMSTWS
Forma física
Lyophilized with no additives.
Reconstitución
Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
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The complex binding mode of the peptide hormone H2 relaxin to its receptor RXFP1.
Sethi A, et al.
Nature Communications, 7, 11344-11344 (2016)
Evolution of the relaxin/insulin-like gene family in anthropoid primates.
Arroyo JI, et al.
Genome Biology and Evolution, 6, 491-499 (2014)
Dual blockade of PKA and NF-?B inhibits H2 relaxin-mediated castrate-resistant growth of prostate cancer sublines and induces apoptosis.
Vinall RL, et al.
Hormones & Cancer, 2, 224-238 (2011)
Human relaxin-2: historical perspectives and role in cancer biology.
Nair VB, et al.
Amino Acids, 43, 1131-1140 (2012)
Testosterone reduces knee passive range of motion and expression of relaxin receptor isoforms via 5a-dihydrotestosterone and androgen receptor binding.
Dehghan F, et al.
International Journal of Molecular Sciences, 15, 4619-4634 (2014)
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