Saltar al contenido
Merck
Todas las fotos(1)

Key Documents

View All Documentation

SML1822

Sigma-Aldrich

Akebia saponin D

≥98% (HPLC)

Sinónimos:

3-O-α-L-arabinopyranosyl hederagenin-28-β-D-glucopyranoside-(1→6)-β-D-glucopyranoside, ASD, Asperosaponin VI, Leiyemudanoside A, Tauroside St-G0-1

Iniciar sesiónpara Ver la Fijación de precios por contrato y de la organización
Todas las fotos(1)

About This Item

Fórmula empírica (notación de Hill):
C47H76O18
Número de CAS:
39524-08-8
Peso molecular:
929.10
UNSPSC Code:
12352200
NACRES:
NA.77

biological source

(Dipsacus asper)

Quality Level

100

assay

≥98% (HPLC)

form

powder

optical activity

[α]/D +13 to +18°, c = 0.5 in methanol

storage condition

desiccated

color

white to beige

solubility

H2O: 3 mg/mL, clear (warmed)

shipped in

wet ice

storage temp.

−20°C

SMILES string

CC1(C)CC[C@]2(C(O[C@@H]3O[C@H](CO[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)[C@@H](O)[C@H](O)[C@H]3O)=O)CC[C@@]5(C)[C@]6(C)CCC7[C@](C)(CO)[C@@H](O[C@]8([H])OC[C@H](O)[C@H](O)[C@H]8O)CC[C@]7(C)[C@@]6([H])CC=C5[C@]2([H])C1

InChI

1S/C47H76O18/c1-42(2)13-15-47(41(59)65-40-37(58)34(55)32(53)26(63-40)20-61-38-36(57)33(54)31(52)25(18-48)62-38)16-14-45(5)22(23(47)17-42)7-8-28-43(3)11-10-29(64-39-35(56)30(51)24(50)19-60-39)44(4,21-49)27(43)9-12-46(28,45)6/h7,23-40,48-58H,8-21H2,1-6H3/t23-,24-,25+,26+,27+,28+,29-,30-,31+,32+,33-,34-,35+,36+,37+,38+,39-,40-,43-,44-,45+,46+,47-/m0/s1

InChI key

CCRXMHCQWYVXTE-HMRSNRLKSA-N

¿Está buscando productos similares? Visita Guía de comparación de productos

Biochem/physiol Actions

Akebia saponin D (ASD) is a bioactive triterpenoid saponin isolated from the rhizome of Dipsacus asper Wall that is used as an anti-osteoporosis drug. Akebia saponin D exhibits therapeutic effects in number of disease models including cancer, Alzheimer′s disease, cardiovascular disease, and bone fractures. Akebia saponin D protects against nonalcoholic fatty liver disease (NAFLD) liver damage in mice model of NAFLD. ASD decreases hepatic steatosis and heptocyte apoptosis through autophagy modulation. Akebia saponin D prevents oleic acid induced lipid droplets accumulation and increases autophagic flux BRL cells.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

¿Ya tiene este producto?

Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.

Visite la Librería de documentos

Li-Li Gong et al.
The Journal of pharmacology and experimental therapeutics, 359(3), 392-400 (2016-10-27)
Nonalcoholic fatty liver disease (NAFLD) is considered to be a hepatic manifestation of the metabolic syndrome, and the incidence of NAFLD is increasing rapidly. However, appropriate drugs for treatment of NAFLD are lacking. This study aimed to elucidate the protective
Xing Yu et al.
Behavioural brain research, 235(2), 200-209 (2012-09-12)
Neuroinflammatory responses caused by amyloid β(Aβ) play an important role in the pathogenesis of Alzheimer's disease (AD). Aβ is known to be directly responsible for the activation of glial cells and induction of apoptosis. Akebia Saponin D (ASD) is extracted
Li-li Gong et al.
Journal of pharmacological sciences, 126(3), 243-252 (2014-10-17)
Akebia saponin D (ASD) is a typical bioactive triterpenoid saponin obtained from the rhizome of Dipsacus asper Wall. Previous studies have found that ASD has a hepatoprotective effect in a mouse model. The purpose of this paper was to explore

Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.

Póngase en contacto con el Servicio técnico