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SML1392

Sigma-Aldrich

FDI-6

≥98% (HPLC)

Sinónimos:

3-Amino-N-(4-fluorophenyl)-6-(2-thienyl)-4-(trifluoromethyl)-thieno[2,3-b]pyridine-2-carboxamide, 3-Amino-N-(4-fluorophenyl)-6-(thiophen-2-yl)-4-(trifluoromethyl)thieno[2,3-b]pyridine-2-carboxamide, NCGC00099374

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About This Item

Fórmula empírica (notación de Hill):
C19H11F4N3OS2
Número de CAS:
313380-27-7
Peso molecular:
437.43
MDL number:
MFCD01416826
UNSPSC Code:
12352200
PubChem Substance ID:
329825840
NACRES:
NA.77

Quality Level

100

assay

≥98% (HPLC)

form

powder (flocculent)

color

white to beige

solubility

DMSO: 10 mg/mL, clear

storage temp.

2-8°C

SMILES string

NC1=C(C(NC2=CC=C(F)C=C2)=O)SC3=C1C(C(F)(F)F)=CC(C4=CC=CS4)=N3

InChI

1S/C19H11F4N3OS2/c20-9-3-5-10(6-4-9)25-17(27)16-15(24)14-11(19(21,22)23)8-12(26-18(14)29-16)13-2-1-7-28-13/h1-8H,24H2,(H,25,27)

InChI key

ZATJMMZPGVDUOM-UHFFFAOYSA-N

Biochem/physiol Actions

FDI-6 is a potent and specific inhibitor of FOXM1 that blocks DNA binding. FDI-6 binds to FOXM1 protein and specifically downregulates FOXM1-activated genes.
Forkhead domain inhibitor-6 (FDI-6) is used to treat anaemia patients because of diminished red blood production. In Hep-2 cells, FDI-6 can stimulate cell death and also helps to prevent cell proliferation, invasion and migration.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number
075M4617V

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Andrew P Sawaya et al.
Nature communications, 11(1), 4678-4678 (2020-09-18)
Diabetic foot ulcers (DFUs) are a life-threatening disease that often result in lower limb amputations and a shortened lifespan. However, molecular mechanisms contributing to the pathogenesis of DFUs remain poorly understood. We use next-generation sequencing to generate a human dataset
Susana Ros et al.
Cancer cell, 38(4), 516-533 (2020-09-26)
PIK3CA, encoding the PI3Kα isoform, is the most frequently mutated oncogene in estrogen receptor (ER)-positive breast cancer. Isoform-selective PI3K inhibitors are used clinically but intrinsic and acquired resistance limits their utility. Improved selection of patients that will benefit from these
Loss of Forkhead box M1 promotes erythropoiesis through increased proliferation of erythroid progenitors
Youn M, et al.
Haematologica, 102(5), 826-834 (2017)
Forkhead domain inhibitor-6 (FDI-6) increases apoptosis and inhibits invasion and migration of laryngeal carcinoma cells by down-regulating nuclear FoxM1
Liu Y, et al.
Chinese Journal of Catalysis, 33(5), 611-616 (2017)
Karan Ulhaka et al.
International journal of molecular sciences, 22(13) (2021-07-03)
Triple-negative breast cancer (TNBC) presents an important clinical challenge, as it does not respond to endocrine therapies or other available targeting agents. FOXM1, an oncogenic transcriptional factor, has reported to be upregulated and associated with poor clinical outcomes in TNBC
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