The potency, active fraction, and water content are not determined for this product. The purity is lot specific and reported in the product Certificate of Analysis. Unfortunately, the product has not been tested for solubility in DMSO. However, various sources report that this material is soluble at up to 100mg/mL in DMS). This information has not been validated. Please navigate to the ‘DOCUMENTATION’ section of the Product Detail Page to access a Certificate: https://www.sigmaaldrich.com/product/sigma/sbr00041#product-documentation
SBR00041
Cefiderocol
Sinónimos:
S-649266
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About This Item
Fórmula empírica (notación de Hill):
C30H34ClN7O10S2
Número de CAS:
Peso molecular:
752.21
Número MDL:
Código UNSPSC:
12352111
NACRES:
NA.76
En este momento no podemos mostrarle ni los precios ni la disponibilidad
Productos recomendados
Ensayo
≥95% (HPLC)
Nivel de calidad
Formulario
solid
idoneidad de la reacción
reagent type: chelator
espectro de actividad antibiótica
Gram-negative bacteria
Modo de acción
protein synthesis | inhibits
temp. de almacenamiento
−20°C
cadena SMILES
NC1=NC(/C(C(N[C@@H]2C(N3[C@@H]2SCC(C[N+]4(CCCC4)CCNC(C5=CC=C(O)C(O)=C5Cl)=O)=C3C([O-])=O)=O)=O)=N/OC(C(O)=O)(C)C)=CS1
InChI
1S/C30H34ClN7O10S2/c1-30(2,28(46)47)48-36-19(16-13-50-29(32)34-16)24(42)35-20-25(43)37-21(27(44)45)14(12-49-26(20)37)11-38(8-3-4-9-38)10-7-33-23(41)15-5-6-17(39)22(40)18(15)31/h5-6,13,20,26H,3-4,7-12H2,1-2H3,(H7-,32,33,34,35,36,39,40,41,42,44,45,46,47)/t20-,26-/m1/s1
Clave InChI
DBPPRLRVDVJOCL-FQRUVTKNSA-N
Descripción general
Cefiderocol has been shown to be effective in preventing the emergence of resistant mutants but is not active against methicillin-resistant Staphylococcus aureus (MRSA) or colistin-resistant bacteria. This versatile compound finds applications in cell biology and biochemical research.
Cefiderocol is a novel injectable siderophore cephalosporin, which was formerly known as S-649266.[1][2] It has a catechol-type siderophore and cephalosporin core and side chains.[1] Cefiderocol has structural similarity with both ceftazidime and cefepime, besides the chlorocatechol group on the end of the C-3 chain.[3]
Aplicación
Cefiderocol has been used:
- study bacterial infections and tracking their uptake in vivo
- the study of the activity of Cefiderocol against gram-negative bacteria[1]
Acciones bioquímicas o fisiológicas
Mode of Action: Cefiderocol binds to specific proteins called penicillin-binding proteins (PBPs) located on the bacterial cell wall. This binding affinity inhibits the synthesis of the bacterial cell wall, leading to cell lysis and bacterial death.
Antimicrobial Spectrum: Cefiderocol has strong antimicrobial properties, especially against a wide spectrum of Gram-negative pathogens.[1][2] Due to its siderophore core it is also a natural iron-chelator, which adds to its antibacterial activities.[1]
Antimicrobial Spectrum: Cefiderocol has strong antimicrobial properties, especially against a wide spectrum of Gram-negative pathogens.[1][2] Due to its siderophore core it is also a natural iron-chelator, which adds to its antibacterial activities.[1]
Características y beneficios
- High-quality antibiotic suitable for multiple research applications
- Ideal for Cell Biology and Biochemical research
Otras notas
For additional information on our range of Biochemicals, please complete this form.
Cláusula de descargo de responsabilidad
The product is not intended for use as a biocide under global biocide regulations, including but not limited to US EPA′s Federal Insecticide Fungicide and Rodenticide Act, European Biocidal Products Regulation, Canada’s Pest Management Regulatory Agency, Turkey’s Biocidal Products Regulation, Korea’s Consumer Chemical Products and Biocide Safety Management Act (K-BPR) and others.
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
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Certificados de análisis (COA)
Lot/Batch Number
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Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.
Janet Y Wu et al.
Infectious diseases and therapy, 9(1), 17-40 (2020-02-20)
Cefiderocol, formerly S-649266, is a first in its class, an injectable siderophore cephalosporin that combines a catechol-type siderophore and cephalosporin core with side chains similar to cefepime and ceftazidime. This structure and its unique mechanism of action confer enhanced stability
Takafumi Sato et al.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 69(Suppl 7), S538-S543 (2019-11-15)
The emergence of antimicrobial resistance is a significant public health issue worldwide, particularly for healthcare-associated infections caused by carbapenem-resistant gram-negative pathogens. Cefiderocol is a novel siderophore cephalosporin targeting gram-negative bacteria, including strains with carbapenem resistance. The structural characteristics of cefiderocol
Justin J Choi et al.
Expert opinion on investigational drugs, 27(2), 193-197 (2018-01-11)
The emergence of multidrug-resistant bacterial pathogens has led to a global public health emergency and novel therapeutic options and drug-delivery systems are urgently needed. Cefiderocol is a siderophore cephalosporin antibiotic that has recently been developed to combat a variety of
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want to know about the following parameters that I need for my studies.Potency,Assay Purity,Active fraction and Water content. I also want to know about concentration of DMSO for stock.
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