SAB4503272

Anti-CASP-1 (Cleaved-Asp²¹⁰) antibody produced in rabbit

affinity isolated antibody

• Sinónimos: ICE, IL-1 β, IL-1 β converting enzyme, IL-1BC, caspase-1
• Código UNSPSC: 12352203
• NACRES: NA.41

Propiedades

• origen biológico: rabbit
• Nivel de calidad: 100
• conjugado: unconjugated
• forma del anticuerpo: affinity isolated antibody
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• Formulario: buffered aqueous solution
• mol peso: antigen 25 kDa; antigen 45 kDa
• reactividad de especies: human
• concentración: ~1 mg/mL
• técnicas: ELISA: 1:10000; immunohistochemistry: 1:50-1:100; western blot: 1:500-1:1000
• Nº de acceso NCBI: P29466
• Nº de acceso UniProt: P29466
• Condiciones de envío: wet ice
• temp. de almacenamiento: −20°C
• modificación del objetivo postraduccional: proteolytically cleaved (Asp210)
• Información sobre el gen: human ... CASP1(834)

Descripción

Descripción general

Anti-CASP-1 (Cleaved-Asp²¹⁰) Antibody detects endogenous levels of fragment of activated CASP-1 (Cleaved-Asp²¹⁰) protein.

Caspase-1 is also known as interleukin-1β converting enzyme (ICE). It is located on human chromosome 11q22.2. It has 10 exons, an N terminal CARD (caspase activation and recruitment domain), a large P20 subunit and a small P10 subunit. CASP-1 is present in leukocytes, monocytes and epithelial cells.

Inmunógeno

The antiserum was produced against synthesized peptide derived from human IL-1 beta.

Immunogen Range: 161-210

Acciones bioquímicas o fisiológicas

Caspase-1 can transform pro-inflammatory cytokines, interleukin-1β (IL-1β) and interleukin-18 (IL-18) into their active forms. It participates in pyroptosis. It is overexpressed in the aorta of coronary atherosclerosis patients. CASP-1 helps in host cell survival by inducing membrane biogenesis to restore the impairment caused by pore-forming toxins.

Características y beneficios

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Forma física

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): nwg
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable