SAB4502139

Anti-PDGFR α antibody produced in rabbit

affinity isolated antibody

• Sinónimos: α platelet-derived growth factor receptor precursor, CD140a, PDGF-R-α, PDGFR-α, kinase PDGFR-α
• Número MDL: MFCD01322518
• Código UNSPSC: 12352203
• NACRES: NA.41

Propiedades

• origen biológico: rabbit
• Nivel de calidad: 100
• conjugado: unconjugated
• forma del anticuerpo: affinity isolated antibody
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• Formulario: buffered aqueous solution
• mol peso: antigen 122 kDa
• reactividad de especies: rat, human, mouse
• concentración: ~1 mg/mL
• técnicas: ELISA: 1:5000; immunofluorescence: 1:100-1:500; immunohistochemistry: 1:50-1:100
• Nº de acceso NCBI: P16234
• Condiciones de envío: wet ice
• temp. de almacenamiento: −20°C
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... PGFRA(5156)

Descripción

Descripción general

Anti-PDGFR Anti-PDGFR α Antibody detects endogenous levels of total PDGFR α protein. Antibody detects endogenous levels of total PDGFR α protein.

Platelet-derived growth factor receptor α (PDGFRA), also known as cluster of differentiation 140a (CD140a), is encoded by the gene mapped to human chromosome 4q12. The encoded protein belongs to the receptor tyrosine kinase gene family.

Inmunógeno

The antiserum was produced against synthesized peptide derived from human PDGFR alpha.

Immunogen Range: 731-780

Acciones bioquímicas o fisiológicas

Platelet-derived growth factor receptor plays a vital role in the development and maturation of platelets. Platelet-derived growth factor receptor α (PDGFRA) acts as a potential target for imatinib, a revolutionary drug for the treatment of chronic myeloid leukemia. PDGFRA pathway might be involved in developmental process of thrombocytes. The encoded protein facilitates hepatic stellate cell (HSCs) proliferation and migration. Mutation in the gene has been observed in gastrointestinal stromal tumors (GISTs).

Características y beneficios

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Forma física

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): nwg
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable